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中华肾病研究电子杂志 ›› 2013, Vol. 02 ›› Issue (06) : 300 -303. doi: 10.3877/cma.j.issn.2095-3216.2013.06.005

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足细胞再生的研究进展
丁国华1,(), 梁伟1, 马屹茕1   
  1. 1.430060 武汉大学人民医院肾内科
  • 出版日期:2013-12-15
  • 通信作者: 丁国华
  • 基金资助:
    国家自然科学基金项目(81270762,81100478)

Research progress in podocyte regeneration

Guo-hua DING1,(), Wei LIANG1, Yi-qiong MA1   

  1. 1.Department of Nephrology, Renmin Hospital of Wuhan University, Wuhan 430060, China
  • Published:2013-12-15
  • Corresponding author: Guo-hua DING
引用本文:

丁国华, 梁伟, 马屹茕. 足细胞再生的研究进展[J/OL]. 中华肾病研究电子杂志, 2013, 02(06): 300-303.

Guo-hua DING, Wei LIANG, Yi-qiong MA. Research progress in podocyte regeneration[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2013, 02(06): 300-303.

足细胞是肾小球滤过屏障的重要组成部分,各种应激和/或损伤因素均可导致足细胞数量的减少,足细胞缺失是肾小球硬化起始和进展的主要原因。 近年研究发现,肾脏可能通过肾脏固有细胞或肾脏前体干细胞再生来代偿缺失的足细胞,在人和啮齿类动物中可能存在三种前体干细胞参与了足细胞再生:骨髓源性干细胞,肾小球壁层上皮细胞和球旁器肾素分泌细胞。 尽管足细胞再生研究取得了一定进展,但仍有许多问题有待进一步探讨。

Podocyte is an important part of glomerular filtration barrier. A variety of stress and/or injury factors may lead to reduction in the number of podocytes, which is the leading cause of glomerulosclerosis initiation and progression. Recent studies have found that kidney stem cells may be regenerated by renal intrinsic cells or precursor stem cells to compensate for the lost podocytes. There are three possible precursor stem cells in humans and rodents that are involved in podocytes regeneration: bone marrow-derived stem cells, glomerular parietal epithelial cells, and juxtaglomerular apparatus renin-secreting cells. Although some progress has been made in research on podocytes regeneration, there are still many issues to be further explored.

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