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中华肾病研究电子杂志 ›› 2015, Vol. 04 ›› Issue (02) : 97 -101. doi: 10.3877/cma.j.issn.2095-3216.2015.02.009

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综述

IgA肾病相关尿液无创性生物标志物的研究进展
王楠楠1, 卜茹1, 蔡广研1, 陈香美1,()   
  1. 1. 100853 北京,解放军总医院肾脏病科、解放军肾脏病研究所、肾脏疾病国家重点实验室、国家慢性肾病临床医学研究中心
  • 出版日期:2015-04-28
  • 通信作者: 陈香美
  • 基金资助:
    国家"863"计划项目(2012AA02A512); 国家"十二五"科技支撑计划项目(2011BAI10B00); 国家自然科学基金项目(81171645); 国家"973"计划项目(2013CB530800)

Research advancement of non-invasive urinary biomarkers associated with IgA nephropathy

Nannan Wang1, Ru Bu1, Guangyan Cai1, Xiangmei Chen1,()   

  1. 1. Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Disease, National Clinical Research Center for Kidney Diseases, Beijing 100853, China
  • Published:2015-04-28
  • Corresponding author: Xiangmei Chen
  • About author:
    Corresponding author: Chen Xiangmei, Email:
引用本文:

王楠楠, 卜茹, 蔡广研, 陈香美. IgA肾病相关尿液无创性生物标志物的研究进展[J]. 中华肾病研究电子杂志, 2015, 04(02): 97-101.

Nannan Wang, Ru Bu, Guangyan Cai, Xiangmei Chen. Research advancement of non-invasive urinary biomarkers associated with IgA nephropathy[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2015, 04(02): 97-101.

IgA肾病(IgAN)是最常见的原发性肾小球疾病,寻找能够用于IgA肾病的诊断、评估病情或判断预后的无创性生物标志物具有非常重要的经济和学术价值。近五年来关于IgA肾病相关尿液无创性生物标志物的研究进展较多,尤其是在足细胞成分、补体蛋白成分、RAS相关蛋白和miRNAs等方面。

IgA nephropathy (IgAN) is the most common primary glomerular disease. It′s of very important economic and academic value to find non-invasive biomarkers that can be used in the diagnosis, assessment, and prognosis of IgA nephropathy. In recent five years, the research on non-invasive urinary biomarkers associated with IgAN has made a remarkable progress, especially in podocytes, complement components, RAS-related proteins, and miRNAs.

表1 IgA肾病相关尿液无创性生物标志物一览表
标志物 来源 表达趋势 能否提示诊断 能否提示预后 与临床指标的相关性
足细胞成分及其标志物 ? ? ? ? ?
? Podocalyxin[3,4,5] 尿液 与急性毛细血管外病变正相关
? Dendrin[6,7] 尿沉渣 与Scr负相关,与eGFR正相关
补体蛋白成分 ? ? ? ? ?
? 甘露糖结合凝集素[9] 尿上清液 与Scr、尿蛋白和病理评分正相关,与eGFR负相关
? 膜攻击复合物[10,11] 尿液 与Scr、尿蛋白、间质纤维化和肾小球硬化正相关
? 补体因子H[10,11] 尿液 与Scr、尿蛋白、间质纤维化和肾小球硬化正相关
? C3a和C5a[12] 尿液 与Scr、尿蛋白和病理分级正相关
RAS相关蛋白 ? ? ? ? ?
? 尿血管紧张素原[14,15] 尿液 与收缩压、尿蛋白/肌酐、滤过分数和肾组织血管紧张素Ⅱ正相关
? 尿液水通道蛋白2[16] 尿上清液 与高血压相关
? 血清和糖皮质激素诱导的蛋白激酶-1[17] 尿液 与Scr、尿蛋白、血尿酸和eGFR正相关
细胞因子 ? ? ? ? ?
? 单核细胞趋化蛋白-1[18] 尿上清液 与毛细血管内增生正相关
? IL-17[18] 尿上清液 与毛细血管内增生正相关
? INF-γ[18] 尿上清液 与毛细血管内增生正相关
? IL-10[18] 尿上清液 与毛细血管内增生正相关
? IL-1β[18] 尿上清液 与Scr、毛细血管内增生和肾小球硬化正相关
? 表皮细胞生长因子[18] 尿上清液 与Scr和肾小球硬化负相关
? IL-6[18,19,20,21] 尿上清液 与毛细血管内增生、肾小球硬化正相关
miRNAs ? ? ? ? ?
? miR-200a[31] 尿沉渣 与蛋白尿负相关
? miR-200b[31] 尿沉渣 与蛋白尿负相关,与GFR正相关
? miR-429[31] 尿沉渣 与蛋白尿和肾小球硬化负相关,与GFR正相关
? miR-146a 尿沉渣 与蛋白尿正相关
? miR-155[32] 尿沉渣 与蛋白尿正相关
? miR-17[33] 尿沉渣 与GFR正相关
其他 ? ? ? ? ?
? 肾损伤分子-1[25,26] 尿上清液 与Scr、尿蛋白正相关
? LG3[29,30] 尿上清液 与Scr、尿蛋白正相关
? 游离κ轻链[29,30] 尿上清液 与蛋白尿、Scr和病理评分负相关
? 尿调节素[27] 尿上清液
? IgA-尿调节素复合物[28] 尿液
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