老年人的肾小球滤过率随年龄增长而逐渐下降，加之基础疾病较多，合并用药现象十分普遍，导致其成为药物性肾损伤的高危人群。老年人如何安全用药成为一个亟待解决的临床问题，然而国内外尚无完善、统一的临床用药指南。本文就此问题介绍了老年人群应避免使用的、具有潜在肾损害的药物，总结出老年安全用药应该遵循的原则，并进一步从中医角度提出医养结合的摄生调护方法，供广大医务工作者参考。

The elderly population has become a high-risk population of drug-induced nephrotoxicity because of persisting declination in glomerular filtration rate with age, multiple underlying health problems, and widespread combination-medication. There is urgent demand for guiding safe medication in elderly population. However, no reliable recommendation can be found worldwide. The current article disclosed potentially nephrotoxic medications that should be avoided in elderly population, summarized principles for safe medication, and furthermore, provided health nursing methods from the viewpoint of traditional Chinese medicine.