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中华肾病研究电子杂志 ›› 2020, Vol. 09 ›› Issue (01) : 45 -47. doi: 10.3877/cma.j.issn.2095-3216.2020.01.010

所属专题: 经典病例 经典病例 文献

病例报告

罕见IgG-γ3型肾脏重链沉积病1例
万兴运1, 陈意志2, 吴奇鲜1, 王滨2, 岳书玲3, 王远大2, 汤力2,(), 于帅4,()   
  1. 1. 572013 三亚,解放军总医院海南医院 肾病科
    2. 572013 三亚,解放军总医院海南医院 肾病科;100853 北京,解放军总医院第一医学中心肾脏病科、解放军肾脏病研究所、肾脏疾病国家重点实验室(2011DAV00088)、国家慢性肾病临床医学研究中心、肾脏疾病研究北京市重点实验室
    3. 510220 广州,广州金域医学检验中心有限公司&肾病病理科
    4. 572013 三亚,解放军总医院海南医院热带医学&感染疾病科;572013 三亚,国家老年疾病临床医学研究中心 解放军总医院海南医院热带医学研究所
  • 收稿日期:2019-08-21 出版日期:2020-02-28
  • 通信作者: 汤力, 于帅

A rare case of IgG-γ3 type renal heavy chain deposition disease

Xingyun Wan1, Yizhi Chen2, Qixian Wu1   

  • Received:2019-08-21 Published:2020-02-28
引用本文:

万兴运, 陈意志, 吴奇鲜, 王滨, 岳书玲, 王远大, 汤力, 于帅. 罕见IgG-γ3型肾脏重链沉积病1例[J]. 中华肾病研究电子杂志, 2020, 09(01): 45-47.

Xingyun Wan, Yizhi Chen, Qixian Wu. A rare case of IgG-γ3 type renal heavy chain deposition disease[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2020, 09(01): 45-47.

图1 肾小球系膜区重度增宽,结节状改变伴PAS阳性物质沉积,毛细血管袢呈分叶状,毛细血管腔受压、狭窄、闭塞(PAS×400倍),
图2 肾小球结节状改变伴纤维细胞性新月体形成,结节硬化区PASM染色阴性(PASM×400倍),
图3 IgG3沿肾小球系膜区沉积及肾小管基底膜类线状沉积(免疫荧光×200倍)
图4 Kappa示肾小球和肾小管基底膜阴性(免疫荧光×200倍),
图5 Lambda示肾小球和肾小管基底膜阴性(免疫荧光×200倍),
图6 肾小球基底膜内侧细泥沙样无定形电子致密物沉积(×2 000倍)
图7 肾小球基底膜内侧细泥沙样无定形电子致密物沉积(×10 000倍),
图8 肾小管基底膜外侧细泥沙样无定形电子致密物沉积(×4 000倍)
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