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中华肾病研究电子杂志 ›› 2024, Vol. 13 ›› Issue (02) : 92 -96. doi: 10.3877/cma.j.issn.2095-3216.2024.02.006

综述

晚期慢性肾脏病患者骨质疏松症的治疗研究进展
肖伍豪1, 刘抗寒1,()   
  1. 1. 410005 长沙,湖南省人民医院(湖南师范大学附属第一医院)肾内科
  • 收稿日期:2022-11-07 出版日期:2024-04-28
  • 通信作者: 刘抗寒
  • 基金资助:
    湖南省自然科学基金项目(2020JJ4405); 湖南省卫生健康委项目(202103051068)

Research progress on the treatment of osteoporosis in patients with advanced chronic kidney disease

Wuhao Xiao1, Kanghan Liu1,()   

  1. 1. Department of Nephrology, Hunan Provincial People′s Hospital/First Hospital Affiliated to Hunan Normal University, Changsha 410005, Hunan Province, China
  • Received:2022-11-07 Published:2024-04-28
  • Corresponding author: Kanghan Liu
引用本文:

肖伍豪, 刘抗寒. 晚期慢性肾脏病患者骨质疏松症的治疗研究进展[J/OL]. 中华肾病研究电子杂志, 2024, 13(02): 92-96.

Wuhao Xiao, Kanghan Liu. Research progress on the treatment of osteoporosis in patients with advanced chronic kidney disease[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2024, 13(02): 92-96.

骨质疏松症是慢性肾脏病(CKD)患者常见的并发症之一,严重影响患者的生存质量及增加病死率。抗骨质疏松药物根据作用机理不同,主要分为骨吸收抑制剂和骨形成促进剂两大类。晚期CKD患者应用抗骨质疏松药物时更容易出现不良反应、增加CKD进展风险。本文综述了晚期CKD患者骨质疏松症的治疗研究进展,以期为临床工作提供帮助。

Osteoporosis is one of the common complications of patients with chronic kidney disease (CKD), and can seriously affect the patients’ quality of life and increase the mortality. According to their mechanisms of action, the anti-osteoporosis drugs are mainly divided into bone resorption inhibitors and osteoanabolic agents. Patients with advanced CKD are more likely to experience adverse effects of anti-osteoporosis drugs, and may have an increased risk of CKD progression. This article reviewed the progress of research on the treatment of osteoporosis in patients with advanced CKD, aiming to provide assistance for clinical work.

表1 高转换型、低转换型骨病发病机制
表2 相关指南共识提出的晚期慢性肾脏病骨质疏松症患者临床管理目标值
表3 慢性肾脏病患者抗骨质疏松症药物适用范围及常见不良反应
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