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中华肾病研究电子杂志 ›› 2012, Vol. 01 ›› Issue (02) : 94 -97. doi: 10.3877/cma.j.issn.2095-3216.2012.02.007

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抗肾小球基底膜肾炎的治疗
刘广义1, 胡昭1,()   
  1. 1.250012 济南,山东大学齐鲁医院肾脏内科
  • 收稿日期:2012-11-08 出版日期:2012-12-18
  • 通信作者: 胡昭

Treatment for anti-glomerular basement membrane nephritis

Guang-yi LIU1, Zhao HU1,()   

  1. 1.Renal Division, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2012-11-08 Published:2012-12-18
  • Corresponding author: Zhao HU
引用本文:

刘广义, 胡昭. 抗肾小球基底膜肾炎的治疗[J/OL]. 中华肾病研究电子杂志, 2012, 01(02): 94-97.

Guang-yi LIU, Zhao HU. Treatment for anti-glomerular basement membrane nephritis[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2012, 01(02): 94-97.

抗肾小球基底膜肾炎主要表现为快速进展性、难治性肾小球肾炎伴或不伴有严重的肺出血,临床救治困难,存活率低。因此,有必要就该病的发病现状、机制及治疗策略、预后影响因素等进行评述。甲泼尼龙、环磷酰胺冲击治疗联合血浆置换为一线治疗方案,可明显提高患者生存率。但肾脏生存率仍较低,早期诊断、早期强化治疗具有重要意义。

The main manifestations of anti-glomerular basement membrane (GBM) nephritis include rapid progressive, refractory glomerulonephritis with or without severe pulmonary hemorrhage,with low survival rates. We summarized the incidence, mechanisms, treatment strategies and prognostic factors of anti-GBM nephritis, under a comprehensive analysis of the latest suggests from Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. We concluded that methyl prednisolone and cyclophosphamide therapy combined with plasma exchange was the first-line therapy for anti-GBM nephritis. Although the survival rate has been greatly increased, the kidney survival rate was still low.Early diagnosis, early intensive treatment was important.

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