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中华肾病研究电子杂志 ›› 2024, Vol. 13 ›› Issue (06) : 327 -333. doi: 10.3877/cma.j.issn.2095-3216.2024.06.005

综述

IgA 肾病的十种治疗措施
国文凯1,2, 纪鹏程1, 毕靖茹1,2, 谢院生1,2,()   
  1. 1.100853 北京,中国人民解放军总医院第一医学中心肾脏病医学部、肾脏疾病全国重点实验室、国家慢性肾病临床医学研究中心、肾脏疾病研究北京市重点实验室
    2.300071 天津,南开大学医学院
  • 收稿日期:2024-08-19 出版日期:2024-12-28
  • 通信作者: 谢院生
  • 基金资助:
    国家自然科学基金(82174115)

Ten treatment measures for IgA nephropathy

Wenkai Guo1,2, Pengcheng Ji1, Jingru Bi1,2, Yuansheng Xie1,2,()   

  1. 1.Department of Nephrology, First Medical Center of Chinese PLA General Hospital,National Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing 100853
    2.Nankai University School of Medicine, Tianjin 300071;China
  • Received:2024-08-19 Published:2024-12-28
  • Corresponding author: Yuansheng Xie
引用本文:

国文凯, 纪鹏程, 毕靖茹, 谢院生. IgA 肾病的十种治疗措施[J/OL]. 中华肾病研究电子杂志, 2024, 13(06): 327-333.

Wenkai Guo, Pengcheng Ji, Jingru Bi, Yuansheng Xie. Ten treatment measures for IgA nephropathy[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2024, 13(06): 327-333.

IgA 肾病是一种病理表现为以IgA 为主的免疫球蛋白在肾小球系膜区域沉积,同时伴系膜细胞和系膜基质增生的自身免疫性疾病。 目前对IgA 肾病尚无统一的治疗方案,在治疗过程中需要结合患者的临床表现、肾脏病理改变与疾病的发病机制等,在权衡疗效和安全性的前提下,对患者进行个性化诊疗。 近年来,随着对IgA 肾病自身免疫发病机制理解的不断深入,传统药物与作用于不同靶点的多种新型药物的联合应用,可以从机制上互补以精准个体化控制IgA 肾病患者病情,从而改善肾脏预后。 本文系统总结了目前IgA 肾病的10 种治疗措施及其相关药物作用机制,旨在加深对IgA 肾病治疗的认识,以期为临床实践提供指导。

IgA nephropathy is an autoimmune disease characterized by IgA-predominant deposition of immunoglobulins in the mesangial area the glomeruli, accompanied by mesangial cell proliferation and mesangial matrix expansion. Currently, there is no unified treatment regimen for IgA nephropathy. In the treatment process, it is necessary to consider the patients’ clinical manifestations, renal pathological changes, and the pathogenesis of the disease. Balancing efficacy and safety, personalized diagnosis and treatment should be provided to the patients. In recent years, with an increasing understanding of the autoimmune pathogenesis of IgA nephropathy, the combined use of traditional medications and various novel agents targeting different pathways can complement each other mechanistically to achieve precise individualized control of the disease, thereby improving renal outcomes. This article systematically summerized the ten treatment measures for IgA nephropathy and the respective action mechanisms of relevant drugs, aiming to deepen understanding of IgA nephropathy treatment and provide guidance for clinical practice.

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