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中华肾病研究电子杂志 ›› 2014, Vol. 03 ›› Issue (01) : 19 -22. doi: 10.3877/cma.j.issn.2095-3216.2014.01.005

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模式生物果蝇在肾脏病研究中的应用进展
张福建1, 陈香美1,()   
  1. 1.100853 北京,解放军总医院肾脏病科、解放军肾脏病研究所、肾脏疾病国家重点实验室、国家慢性肾病临床医学研究中心
  • 出版日期:2014-02-15
  • 通信作者: 陈香美
  • 基金资助:
    国家973 计划项目(2013BAI09B05)

Application progress of model organism Drosophila in the research of kidney disease

Fujian Zhang1, Xiangmei Chen1,()   

  1. 1.Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases,Beijing 100853, China
  • Published:2014-02-15
  • Corresponding author: Xiangmei Chen
引用本文:

张福建, 陈香美. 模式生物果蝇在肾脏病研究中的应用进展[J/OL]. 中华肾病研究电子杂志, 2014, 03(01): 19-22.

Fujian Zhang, Xiangmei Chen. Application progress of model organism Drosophila in the research of kidney disease[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2014, 03(01): 19-22.

果蝇作为经典的模式生物,已经在胚胎发育、基因的表达调控、以及神经系统的发育等生命科学领域得到广泛的应用。 近年来的研究表明,果蝇的肾原细胞在结构上、功能上以及分子水平上与哺乳动物的足细胞和肾小管上皮细胞十分相似。 该文系统性的回顾了果蝇在肾脏疾病研究中应用的发展历史,并展望了果蝇在肾脏疾病研究中的应用前景。

As a classic model organism, Drosophila, has been widely applied in the fields of life sciences including embryonic development, regulation of gene expression, as well as development of nervous system. Recent studies have shown that the nephrocytes of Drosophila are very similar to podocytes and tubular epithelial cells of mammals in cellular structure, functions and molecules. This paper has systematically reviewed the history and look forward to the prospects of Drosophila applications in the research of kidney diseases.

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