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中华肾病研究电子杂志 ›› 2014, Vol. 03 ›› Issue (03) : 143 -146. doi: 10.3877/cma.j.issn.2095-3216.2014.03.006

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尿毒症瘙痒症的发病机制与治疗进展
赵景宏1,(), 王沂芹1, 王代红1   
  1. 1.400037 重庆,第三军医大学新桥医院肾内科、全军肾脏病中心
  • 出版日期:2014-06-15
  • 通信作者: 赵景宏

Progress in the pathogenesis and treatment of uremic pruritus

Jinghong Zhao1,(), Yiqin Wang1, Daihong Wang1   

  1. 1.Department of Nephrology, Xinqiao Hospital, Kidney Center of PLA, Third Military Medical University, Chongqing 400037, China
  • Published:2014-06-15
  • Corresponding author: Jinghong Zhao
引用本文:

赵景宏, 王沂芹, 王代红. 尿毒症瘙痒症的发病机制与治疗进展[J/OL]. 中华肾病研究电子杂志, 2014, 03(03): 143-146.

Jinghong Zhao, Yiqin Wang, Daihong Wang. Progress in the pathogenesis and treatment of uremic pruritus[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2014, 03(03): 143-146.

尿毒症瘙痒症严重影响着终末期肾病患者的生活质量,其发病机制较为复杂,治疗效果有限,一直是困扰患者和医生的临床难题。 本文介绍了免疫炎症假说、阿片类物质假说、皮肤干燥症、血浆组胺水平、高磷和高钙血症等尿毒症瘙痒症的发病机制;同时探讨了尿毒症瘙痒症的治疗进展。

Uremic pruritus, whose pathogenesis is complex with limited efficacy of treatment,impacts seriously on the life quality of patients with end-stage renal disease, and has always been a problem for both uremic patients and doctors. In this paper, factors involved in the pathogenesis of uremic pruritus have been introduced, including immune inflammation hypothesis, opioid hypothesis, skin xerosis, plasma histamine level, hyperphosphatemia and hypercalcemia, etc. Besides, the treatment progress of uremic pruritus is also discussed.

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