切换至 "中华医学电子期刊资源库"

中华肾病研究电子杂志 ›› 2014, Vol. 03 ›› Issue (05) : 236 -240. doi: 10.3877/cma.j.issn.2095-3216.2014.05.003

专家论坛

调脂药在肾脏病中的合理应用
李英1,()   
  1. 1.050086 石家庄,河北医科大学第三医院肾内科河北省肾脏病研究中心
  • 出版日期:2014-10-15
  • 通信作者: 李英

Reasonable application of antilipemic agents in patients with kidney diseases

Ying Li1,()   

  1. 1.Department of Nephrology, Third Hospital, Hebei Medical University, Shijiazhuang 050086,China
  • Published:2014-10-15
  • Corresponding author: Ying Li
引用本文:

李英. 调脂药在肾脏病中的合理应用[J/OL]. 中华肾病研究电子杂志, 2014, 03(05): 236-240.

Ying Li. Reasonable application of antilipemic agents in patients with kidney diseases[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2014, 03(05): 236-240.

目前,我国高脂血症发病率逐年增高,资料显示,血脂异常患病率已高达18.2%,已成为我国居民的一个重要公共卫生问题。 临床研究证实,慢性肾脏病和血脂异常关系密切,两者相互促进,互为因果,理想的血脂水平有助于改善慢性肾脏病(CKD)患者的长期预后。 CKD 患者血脂异常,首先应调整生活方式,积极治疗原发病,重点强调的是根据血脂异常的不同类型,合理选用调脂药物,以达靶目标值,从而延缓CKD 病程的进展。

Currently, the morbidity of hyperlipemia in our country has increased year by year. And data showed that the prevalence of dyslipidemia has been as high as 18.2%, which has become an important public health problem of residents in our country. Clinical studies have confirmed that dyslipidemia is closely related to chronic kidney disease (CKD). They cause, affect, and promote each other. Ideal lipid level helps to improve the long-term prognosis of patients with CKD. CKD patients with dyslipidemia, first of all,should adjust the life style and had their primary diseases treated actively. What is important is to reasonably select antilipemic agents according to the different types of dyslipidemia, in order to achieve the target value and delay the progression of CKD course.

1
Wu Y, Liu X, Li X, et al. Estimation of 10-year risk of fatal and nonfatal ischemic cardiovascular diseases in chinese adults [J].Circulation,2006,114(21):2217-2225.
2
EuropeanAssociationforCardiovascularPrevention&Rehabilitation, Reiner Z,Catapano AL,et al. ESC/EAS Guidelines for the management of dyslipidaemias: The task force for the management of dyslipidaemias of the European Society of Cardiology(ESC) and the European Atherosclerosis Society( EAS) [J]. Eur Heart J,2011,32(14):1769-1818.
3
Liu Y, Coresh J, Eustace JA, et al. Association between cholesterol level and mortality in dialysis patients: role of inflammation and malnutrition [J]. JAMA,2004,291 (4):451-459.
4
D'Agostino RB Sr, Vasan RS, Pencina MJ, et al. General cardiovascular risk profile for use in primary care: the Framingham heart study [J]. Circulation,2008,117(6):743-753.
5
Muntner P,He J,Astor BC,et al. Traditional and nontraditional risk factors predict coronary heart disease in chronic kidney disease:results from the atherosclerosis risk in communities study [J]. J Am Soc Nephrol,2005,16(2):529-538.
6
Libby P. The forgotten majority: unfinished business in cardiovascular risk reduction [J]. J Am Coll Cardiol, 2005, 46(7):1225-1228.
7
NKF-K/DOQI 慢性肾脏病血脂异常管理的临床实践指南[J].中国血液净化,2007,6(12):672-681.
8
Sharp Collaborative Group. Study of Heart and Renal Protection(SHARP): randomized trial to assess the effects of lowering lowdensity lipoprotein cholesterol among 9,438 patients with chronic kidney disease[J]. Am Heart J,2010,160(5):785-794.
9
Alcala A, Jansen S, Tellez T, et al. Statins improve visual field alterations related to hypercholesterolemia [ J]. Athrosclerosis,2010,269(2):512-514.
10
Fried LF, Orchard TJ, Kasiske BL. The effect of lipid reduction on renal disease progression: a meta-analysis. Kidney Int, 2001, 59(1):260-269.
11
Sabrina S, Natasha W, Linda FF, et al. Statins for improving renal outcomes: a meta-analysis [J]. J Am Soc Nephrol,2006,17(7):2006-2016.
12
Cholesterol Treatment Trialists' (CTT) Collaboration, Baigent C,Blackwell L, et al.Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials[J].Lancet,2010,376(9753):1670-1681.
13
Olsson B, Gigante B,Mehlig K, et al. Apolipoprotein C-1 genotype and serum levels of triglycerides, C-reactive protein and coronary heart disease [J]. Metabolism,2010,19(12):1736-1741.
14
National Kidney Foundation. KDOQITM Clinical Practice Guidelines and Clinical Practice Recommendations for Diabetes and Chronic Kidney Disease[J]. Am J Kidney Dis, 2007, 49(Suppl 2): S1-S180.
15
郭丹杰, 徐成斌. 贝特类调脂药物在降脂领域的地位及认识[J].临床药物治疗杂志,2008,6(2):1-3.
16
Aim-High Investigators. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy[J]. N Engl J Med, 2011,365(24):2255-2267.
17
Huxley RR, Barzi F, Lam TH, et al. Isolated low levels of highdensity lipoprotein cholesterol are associated with an increased risk of coronary heart disease: an individual participant data metaanalysis of 23 studies in the asia-pacific region [J]. Circulation,2011,124(19):2056-2064.
18
Baigent C, Landray MJ, Reith C, et al. The effects of lowering LDL cholester-ol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection):a randomised placebo-controlled trial[J]. Lancet, 2011, 377 (9784): 2181-2192.
19
Siscovick DS, Lemaitre RN, Mozaffarian D. The fish story: a dietheart hypothesis with clinical implications: N-3 polyunsaturated fatty acids,myocardial vulnerability,and sudden death [J]. Circulation,2003,107(21):2632-2634.
20
Ozsoy RC, Kastelein JJ, AriszL, et al. A torvas tat in and the dys lip -idem ia of early renal failure [J]. Atherosclerosis, 2003, 166(1) :187-194.
21
ACCORD Study Group.Effects of combination lipid therapy in type 2 diabetes mellitus[J].N Engl J Med,2010,362(17):1563-1574.
22
Baigent C,Landry M. Study of heart and renal protection (SHARP)[J]. Kidney Int,2003,63(Suppl 84): S207-S210.
[1] 史学兵, 谢迎东, 谢霓, 徐超丽, 杨斌, 孙帼. 声辐射力弹性成像对不可切除肝细胞癌门静脉癌栓患者放射治疗效果的评价[J/OL]. 中华医学超声杂志(电子版), 2024, 21(08): 778-784.
[2] 易柏成, 李旭光, 王容容, 王新璇. 数字化3D打印导板应用于上前牙钙化根管治疗2例[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(06): 385-390.
[3] 曹琮沅, 黄烁金, 何倩婷, 王安训. 平阳霉素复合剂治疗口腔颌面部脉管畸形的有效性和安全性[J/OL]. 中华口腔医学研究杂志(电子版), 2024, 18(06): 368-374.
[4] 李华志, 曹广, 刘殿刚, 张雅静. 不同入路下行肝切除术治疗原发性肝细胞癌的临床对比[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 52-55.
[5] 陈浩, 王萌. 胃印戒细胞癌的临床病理特征及治疗选择的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 108-111.
[6] 刘柏隆, 周祥福. 压力性尿失禁阶梯治疗的项目介绍[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 125-125.
[7] 刘柏隆. 女性压力性尿失禁阶梯治疗之手术治疗方案选择[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 126-126.
[8] 石海波, 赵旭东, 王聪, 曲巍. 气肿性肾盂肾炎、气肿性膀胱炎并脓毒性休克一例报道并文献复习[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(06): 644-647.
[9] 林逸, 钟文龙, 李锴文, 何旺, 林天歆. 广东省医学会泌尿外科疑难病例多学科会诊(第15期)——转移性膀胱癌的综合治疗[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(06): 648-652.
[10] 中华医学会器官移植学分会. 肝移植术后缺血性胆道病变诊断与治疗中国实践指南[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 739-748.
[11] 陈伟杰, 何小东. 胆囊癌免疫靶向治疗进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 763-768.
[12] 王誉英, 刘世伟, 王睿, 曾娅玲, 涂禧慧, 张蒲蓉. 老年乳腺癌新辅助治疗病理完全缓解的预测因素分析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 641-646.
[13] 崔军威, 蔡华丽, 胡艺冰, 胡慧. 亚甲蓝联合金属定位夹及定位钩针标记在乳腺癌辅助化疗后评估腋窝转移淋巴结的临床应用价值探究[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 625-632.
[14] 张平骥, 徐钰, 李天水, 庞文翼, 符师宁, 张梦圆. 重症患者镇静治疗现状及期望的调查研究[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 562-567.
[15] 王昌前, 林婷婷, 宁雨露, 王颖杰, 谭文勇. 光免疫治疗在肿瘤领域的临床应用新进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(06): 575-583.
阅读次数
全文


摘要