抗生素在肾脏病中的合理应用

doi:10.3877/cma.j.issn.2095-3216.2014.05.002

中华肾病研究电子杂志 ›› 2014, Vol. 03 ›› Issue (05) : 233 -235. doi: 10.3877/cma.j.issn.2095-3216.2014.05.002

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抗生素在肾脏病中的合理应用

方敬爱¹^,^†(

), 张晓东¹

1.030001 太原,山西医科大学第一医院肾内科

出版日期:2014-10-15
通信作者: 方敬爱

Reasonable application of antibiotics in kidney disease

Jingai Fang¹^,^†(), Xiaodong Zhang¹

1.Department of Nephrology, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China

Published:2014-10-15
Corresponding author: Jingai Fang

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与正常肾功能的患者相比,慢性肾脏病(CKD)患者的药物动力学显著不同,在CKD 患者中应适当调整经肾脏排泄的抗生素剂量或给药间隔时间,否则可能增加药物的毒副作用。对于慢性肾衰竭患者的血液净化治疗,常导致抗生素血药浓度降低,为了维持其有效治疗作用,需要在血液透析治疗期间及之后补充药物剂量。本文将具体讨论如何在肾脏病患者中合理应用抗生素。

关键词: 抗生素, 肾脏病

The pharmacokinetics in patients with chronic kidney disease (CKD) is quite different from that in patients with normal renal function. In patients with CKD,the dose or dosing interval of antibiotics excreted by kidneys should be adjusted appropriately,otherwise the side effects of the drugs may be increased.In contrast, blood purification treatment in patients with chronic renal failure, often results in the decrease of blood concentration of antibiotics. In order to maintain the consistent efficacy of antibiotic drugs,supplemental dosing during or after hemodialysis is sometimes required for patients with end-stage renal disease (ESRD).This article will discuss specifically how to reasonably apply antibiotics in patients with kidney diseases.

Key words: Antibiotic, Kidney disease

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