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中华肾病研究电子杂志 ›› 2015, Vol. 04 ›› Issue (02) : 69 -73. doi: 10.3877/cma.j.issn.2095-3216.2015.02.003

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尿酸性肾病的中西医结合治疗进展
汪年松1,(), 桂定坤1   
  1. 1. 200233 上海交通大学附属第六人民医院肾脏内科
  • 出版日期:2015-04-28
  • 通信作者: 汪年松

Treatment of uric acid nephropathy with integrated traditional Chinese and western medicine

Niansong Wang1,()   

  1. 1. Department of Nephrology, Sixth People′s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China
  • Published:2015-04-28
  • Corresponding author: Niansong Wang
  • About author:
    Corresponding author: Wang Niansong, Email:
引用本文:

汪年松, 桂定坤. 尿酸性肾病的中西医结合治疗进展[J]. 中华肾病研究电子杂志, 2015, 04(02): 69-73.

Niansong Wang. Treatment of uric acid nephropathy with integrated traditional Chinese and western medicine[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2015, 04(02): 69-73.

随着经济和社会的发展及人民生活水平的提高,我国高尿酸血症(HUA)的患病率逐年升高。HUA可造成多脏器损害。尿酸性肾病是尿酸结晶沉积于肾脏而引起的病变。目前,中西医结合治疗已应用于尿酸性肾病。西医通过抑制尿酸合成,促进尿酸排泄,抑制炎症等途径缓解高尿酸血症。尿酸酶类药物是近年来降低尿酸的一类新药,包括重组黄曲霉菌尿酸氧化酶,聚乙二醇化重组尿酸氧化酶。中药单剂鸡矢藤提取物、金刚藤提取物、槲皮素和芦丁提取物在减轻高尿酸血症、保护肾脏方面有积极作用;中药复方中的二妙丸、四妙汤以及四物汤联合二妙散可抑制高尿酸血症,改善肾功能。因此,尿酸性肾病应重视中西医结合治疗。

With the development of economy and society, and the improvement of people′s living standard, the prevalence of hyperuricemia increases year by year in China, which can cause multiple organ damage. Uric acid nephropathy is a disease due to deposit of urate crystals in the kidney. At present, integrated traditional Chinese medicine and western medicine have been used in the treatment of uric acid nephropathy. In western medicine, hyperuricemia can be ameliorated by inhibiting uric acid synthesis, promoting excretion of uric acid, and suppressing inflammation, and so on. Uricase is a new class of drugs to reduce uric acid in recent years, including rasburicase and PEG-uricase. Single agents of traditional Chinese medicine, such as iridiod glycosides from paederia scandens, ethanol extract of rhizoma smilasic chinae, quercetin, and rutin, have positive roles in relieving hyperuricemia and protecting kidney. Compounds of traditional Chinese medicine, including Ermiao pill, Simiao decoction, and Siwu decoction combined with Ermiao powder can inhibit the hyperuricemia so as to improve renal function. Therefore, integrated traditional Chinese medicine and western medicine are important in the treatment of uric acid nephropathy.

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