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中华肾病研究电子杂志 ›› 2015, Vol. 04 ›› Issue (04) : 177 -181. doi: 10.3877/cma.j.issn.2095-3216.2015.04.003

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激素抵抗肾病综合征的中西医结合治疗
鲁盈1()   
  1. 1. 310012 杭州,浙江省立同德医院肾内科
  • 出版日期:2015-08-28
  • 通信作者: 鲁盈

Treatment of steroid-resistant nephrotic syndrome with integrative traditional Chinese and western medicine

Ying Lu1,()   

  1. 1. Department of Nephrology, Zhejiang Provincial Tongde Hospital, Hangzhou, Zhejiang 310012, China
  • Published:2015-08-28
  • Corresponding author: Ying Lu
  • About author:
    Corresponding author: Lu Ying, Email:
引用本文:

鲁盈. 激素抵抗肾病综合征的中西医结合治疗[J]. 中华肾病研究电子杂志, 2015, 04(04): 177-181.

Ying Lu. Treatment of steroid-resistant nephrotic syndrome with integrative traditional Chinese and western medicine[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2015, 04(04): 177-181.

糖皮质激素(激素)抵抗型肾病综合征(SRNS)是肾脏病临床常见的疑难病症之一,属难治性肾病综合征。已有越来越多的学者探索中西医结合治疗方法,以提高临床疗效及缓解长期大剂量免疫抑制剂所带来的副反应。笔者在本文中系统阐述了产生激素抵抗的机制和影响激素疗效的因素,提出应注重规范化治疗,将中医辨"病"治疗的雷公藤制剂联合个体化的辨"证"治疗、传统辨证与微观辨证相结合,组方选药结合中药现代研究结果,是中西医结合治疗SRNS可借鉴的方法。

Steroid-resistant nephrotic syndrome (SRNS) is one of the common difficult kidney diseases in clinical practice, and belongs to intractable nephrotic syndrome. A growing number of scholars have been exploring treatment with integrative traditional Chinese and western medicine so as to improve clinical efficacy and ease the side effects from long-term use of high-dose immunosuppressants. In this article, the author systematically described steroid-resistance mechanism and factors affecting the effect of the steroid, and proposed to pay attention to standardized treatment. The following methods are worth using for reference in treatment of SRNS, including combination of tripterygium wilfordii preparation as "disease" differentiation treatment of traditional Chinese medicine with individualized dialectical treatment, combination of traditional syndrome differentiation and microcosmic syndrome differentiation, and combination of prescription selection with modern research results of traditional Chinese medicine.

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