切换至 "中华医学电子期刊资源库"

中华肾病研究电子杂志 ›› 2016, Vol. 05 ›› Issue (01) : 5 -9. doi: 10.3877/cma.j.issn.2095-3216.2016.01.002

所属专题: 文献

专家论坛

慢性肾脏病患者降压药物的合理选用
何娅妮1,(), 林利容1   
  1. 1. 400042 重庆,第三军医大学大坪医院野战外科研究所肾内科
  • 收稿日期:2015-11-03 出版日期:2016-02-28
  • 通信作者: 何娅妮

Rational selection and application of anti- hypertensive drugs in patients with chronic kidney disease

Yani He1,(), Lirong Lin1   

  1. 1. Department of Nephrology, Daping Hospital, Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China
  • Received:2015-11-03 Published:2016-02-28
  • Corresponding author: Yani He
  • About author:
    Corresponding author: He Yani, Email:
引用本文:

何娅妮, 林利容. 慢性肾脏病患者降压药物的合理选用[J/OL]. 中华肾病研究电子杂志, 2016, 05(01): 5-9.

Yani He, Lirong Lin. Rational selection and application of anti- hypertensive drugs in patients with chronic kidney disease[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2016, 05(01): 5-9.

高血压作为心血管疾病传统的危险因素,在慢性肾脏病(CKD)的发展中起到了重要作用。它既是导致CKD的主要病因,也是CKD最常见的并发症。控制CKD患者血压达标不仅有利于延缓CKD进展,还可降低心血管事件发生。但CKD患者病因复杂、疾病阶段不一,降压药物的合理选用极为重要。

As a traditional risk factor for cardiovascular disease, hypertension plays a critical role in the progression of chronic kidney disease (CKD). Hypertension is not only one of the major causes of CKD, but the most common complication of it. Hypertension management can help to both delay the progression of CKD and reduce the incidence of cardiovascular events. Because the etiology and progression of CKD are complex, the rational selection and application of anti- hypertensive drugs are very important..

1
Segall L, Oprisiu R, Fournier A, et al. Antihypertensive treatment and stroke prevention in patients with and without chronic kidney disease: a review of controlled trials [J]. J Nephrol, 2008, 21(3): 374-83.
2
Heerspink HJ, Ninomiya T, Zoungas S, et al. Effect of lowering blood pressure on cardiovascular events and mortality in patients on dialysis: a systematic review and meta- analysis of randomised controlled trials [J]. Lancet, 2009, 373(9668): 1009-1015.
3
Mancia G, De Backer G, Dominiczak A, et al. 2007 ESH- ESC practice guidelines for the management of arterial hypertension: ESH- ESC task force on the management of arterial hypertension [J]. J Hypertens, 2007, 25(9): 1751-1762.
4
Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) [J]. J Hypertens, 2013, 31(7): 1281-1357.
5
James PA, Oparil S, Carter BL, et al. 2014 evidence- based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8) [J]. JAMA, 2014, 311(5): 507-520.
6
中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华高血压杂志,2011,19(8): 701-742.
7
Appel L, Wright JT Jr, Greene T. Intensive blood- pressure control in hypertensive chronic kidney disease [J]. N Engl J Med, 2010, 363(10): 918-929.
8
Ruggenenti P, Perna A, Loriga G, et al. Blood- pressure control for reno- protection in patients with non- diabetic chronic renal disease (REIN- 2): multicentre, randomised controlled trial [J]. Lancet, 2005, 365(9463): 939-946.
9
KDIGO Work Group. KDIGO clinical practice guideline for the management of blood pressure in chronic kidney disease [J]. Kidney Inter Suppl, 2012, 2(5): 337-414.
10
Raymond R. Blood pressure targets in CKD [J]. Adv Chronic Kidney Dis, 2015, 22(2): 96-101.
11
Kovesdy CP, Bleyer AJ, Molnar MZ, et al. Blood pressure and mortality in US veterans with chronic kidney disease: a cohort study [J]. Ann Intern Med, 2013, 159(4): 233-242.
12
Poulter NR, Prabhakaran D, Caulfield M. Hypertension [J]. Lancet, 2015, 386(9995): 801-812.
13
Cohen HW, Hailpern SM, Fang J, et al. Sodium intake and mortality in the NHANES II follow- up study [J]. Am J Med, 2006, 119(3): 275.e7-275.e14.
14
O′Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events [J]. N Engl J Med, 2014, 371(7): 612-623.
15
Humalda JK, Navis G. Dietary sodium restriction: a neglected therapeutic opportunity in chronic kidney disease [J]. Curr Opin Nephrol Hypertens, 2014, 23(6): 533-540.
16
Burnier M, Wuerzner G. Chronic kidney disease: Should sodium intake be restricted in patients with CKD [J]? Nat Rev Nephrol, 2014, 10(7): 363-364.
17
Fan Li, Tighiouart H, Levey AS, et al. Urinary sodium excretion and kidney failure in nondiabetic chronic kidney disease [J]. Kidney Int, 2014, 86(3): 582-588.
18
Wright JT Jr, Bakris G, Greene T, et al. Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial [J]. JAMA, 2002, 288(19): 2421-2431.
19
Tocci G, Volpe M. End- organ protection in patients with hypertension: focus on the role of angiotensin receptor blockers on renal function [J]. Drugs, 2011, 71(8): 1003-1017.
20
Vishram JK, Borglykke A, Andreasen AH, et al. Impact of age on the importance of systolic and diastolic blood pressures for stroke risk: the MOnica, Risk, Genetics, Archiving, and Monograph (MORGAM) Project [J]. Hypertension, 2012, 60(5): 1117-1123.
21
Balamuthusamy S, Srinivasan L, Verma M, et al. Renin angiotensin system blockade and cardiovascular outcomes in patients with chronic kidney disease and proteinuria: a meta- analysis[J]. Am Heart J, 2008, 155(5): 791-805.
22
Chan KE, Ikizler TA, Gamboa JL, et al. Combined angiotensin converting enzyme inhibition and receptor blockade associate with increased risk of cardiovascular death in hemodialysis patients [J]. Kidney Int, 2011, 80(9): 978-985.
23
Ryan MJ, Tuttle KR. Elevations in serum creatinine with RAAS blockade: why isn't it a sign of kidney injury [J]? Curr Opin Nephrol Hypertens, 2008, 17(5): 443-449.
24
Bakris GL, Weir MR. Angiotensin- converting enzyme inhibitor- associated elevations in serum creatinine: is this a cause for concern [J]? Arch Intern Med, 2000, 160(5): 685-693.
25
K/DOQI Workgroup. K/DOQI clinical practice guidelines for cardiovascular disease in dialysis patients [J]. Am J Kidney Dis, 2005, 45(4 Suppl 3): S1-S153.
26
Palmer SC, Mavridis D, Navarese E, et al. Comparative efficacy and safety of blood pressure- lowering agents in adults with diabetes and kidney disease: a network meta- analysis[J]. Lancet, 2015, 385(9982): 2047-2056.
27
Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta- analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies [J]. BMJ, 2009, 338: b1665.
28
Dahlöf B, Devereux RB, Kjeldsen SE, et al. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol [J]. Lancet, 2002, 359(9311): 995-1003.
29
Ptinopoulou AG, Pikilidou M, Lasaridis AN. The effect of antihypertensive drugs on chronic kidney disease: a comprehensive review [J]. Hypertens Res, 2013, 36(2): 91-101.
30
Badve SV, Roberts MA, Hawley CM, et al. Effects of beta- adrenergic antagonists in patients with chronic kidney disease: a systematic review and meta- analysis [J]. J Am Coll Cardiol, 2011, 58(11): 1152-1161.
31
Tangri N, Shastri S, Tighiouart H, et al. β- Blockers for prevention of sudden cardiac death in patients on hemodialysis: a propensity score analysis of the HEMO Study [J]. Am J Kidney Dis, 2011, 58(6): 939-945.
32
Bakris GL, Sarafidis PA, Weir MR, et al. Renal outcomes with different fixed- dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a pre- specified secondary analysis of a randomised controlled trial [J]. Lancet, 2010, 375(9721): 1173-1181.
33
Mann JF, Anderson C, Gao P. Dual inhibition of the renin- angiotensin system in high- risk diabetes and risk for stroke and other outcomes: results of the ONTARGET trial [J]. J Hypertens, 2013, 31(2): 414-421.
34
Agarwal R, Flynn J, Pogue V, et al. Assessment and management of hypertension in patients on dialysis [J]. J Am Soc Nephrol, 2014, 25(8): 1630-1646.
35
Agarwal R, Satyan S, Alborzi P, et al. Home blood pressure measurements for managing hypertension in hemodialysis patients [J]. Am J Nephrol, 2009, 30(2): 126-134.
36
Lingerfelt K, Hodnicki D. Hypertension management in patients receiving hemodialysis: the benefits of home blood pressure monitoring [J]. Nephrol Nurs J, 2012, 39(1): 31-36.
37
Haskin O, Wong CJ, McCabe L. 44- h ambulatory blood pressure monitoring: revealing the true burden of hypertension in pediatric hemodialysis patients [J]. Pediatr Nephrol, 2015, 30(4): 653-660.
38
Ram CV, Fenves AZ. Management of hypertension in hemodialysis patients [J]. Curr Hypertens Rep, 2009, 11(4): 292-298.
39
Tang X, Hu X, Mei C, et al. Improvement of resistant hypertension by nocturnal hemodialysis in a patient with end- stage kidney disease [J]. Case Rep Nephrol Dial, 2015, 5(1): 60-65.
40
Kestenbaum B, Gillen DL, Sherrard DJ, et al. Calcium channel blocker use and mortality among patients with end- stage renal disease [J]. Kidney Int, 2002, 61(6): 2157-2164.
41
Cice G, Ferrara L, D'Andrea A, et al. Carvedilol increases two- year survival in dialysis patients with dilated cardiomyopathy: a prospective, placebo- controlled trial [J]. J Am Coll Cardiol, 2003, 41(9): 1438-1444.
42
Agarwal R, Sinha AD, Pappas MK, et al. Hypertension in hemodialysis patients treated with atenolol or lisinopril: a randomized controlled trial [J]. Nephrol Dial Transplant, 2014, 29(3): 672-681.
[1] 史学兵, 谢迎东, 谢霓, 徐超丽, 杨斌, 孙帼. 声辐射力弹性成像对不可切除肝细胞癌门静脉癌栓患者放射治疗效果的评价[J/OL]. 中华医学超声杂志(电子版), 2024, 21(08): 778-784.
[2] 李华志, 曹广, 刘殿刚, 张雅静. 不同入路下行肝切除术治疗原发性肝细胞癌的临床对比[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 52-55.
[3] 陈浩, 王萌. 胃印戒细胞癌的临床病理特征及治疗选择的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2025, 19(01): 108-111.
[4] 梁孟杰, 朱欢欢, 王行舟, 江航, 艾世超, 孙锋, 宋鹏, 王萌, 刘颂, 夏雪峰, 杜峻峰, 傅双, 陆晓峰, 沈晓菲, 管文贤. 联合免疫治疗的胃癌转化治疗患者预后及术后并发症分析[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 619-623.
[5] 许月芳, 刘旺, 曾妙甜, 郭宇姝. 多粘菌素B和多粘菌素E治疗外科多重耐药菌感染临床疗效及安全性分析[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(06): 700-703.
[6] 刘柏隆, 周祥福. 压力性尿失禁阶梯治疗的项目介绍[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 125-125.
[7] 刘柏隆. 女性压力性尿失禁阶梯治疗之手术治疗方案选择[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2025, 19(01): 126-126.
[8] 王秋生. 胆道良性疾病诊疗策略[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 779-782.
[9] 中华医学会器官移植学分会. 肝移植术后缺血性胆道病变诊断与治疗中国实践指南[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 739-748.
[10] 陈伟杰, 何小东. 胆囊癌免疫靶向治疗进展[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 763-768.
[11] 公宇, 廖媛, 尚梅. 肝细胞癌TACE术后复发影响因素及预测模型建立[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 818-824.
[12] 李一帆, 朱帝文, 任伟新, 鲍应军, 顾俊鹏, 张海潇, 曹耿飞, 阿斯哈尔·哈斯木, 纪卫政. 血GP73水平在原发性肝癌TACE疗效评价中的作用[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 825-830.
[13] 魏志鸿, 刘建勇, 吴小雅, 杨芳, 吕立志, 江艺, 蔡秋程. 肝移植术后急性移植物抗宿主病的诊治(附四例报告)[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(06): 846-851.
[14] 崔军威, 蔡华丽, 胡艺冰, 胡慧. 亚甲蓝联合金属定位夹及定位钩针标记在乳腺癌辅助化疗后评估腋窝转移淋巴结的临床应用价值探究[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 625-632.
[15] 王誉英, 刘世伟, 王睿, 曾娅玲, 涂禧慧, 张蒲蓉. 老年乳腺癌新辅助治疗病理完全缓解的预测因素分析[J/OL]. 中华临床医师杂志(电子版), 2024, 18(07): 641-646.
阅读次数
全文


摘要


AI


AI小编
你好!我是《中华医学电子期刊资源库》AI小编,有什么可以帮您的吗?