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中华肾病研究电子杂志 ›› 2017, Vol. 06 ›› Issue (04) : 165 -168. doi: 10.3877/cma.j.issn.2095-3216.2017.04.006

所属专题: 文献

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激素抵抗型肾病综合征中西医治疗进展
鲁盈1,(), 傅文宁1   
  1. 1. 310012 浙江省立同德医院 肾内科
  • 收稿日期:2017-05-15 出版日期:2017-08-28
  • 通信作者: 鲁盈
  • 基金资助:
    国家自然科学基金(81273982,81673818); 浙江省中医药科技计划重点项目(2012ZZ001)

Progress in treatment of steroid-resistant nephrotic syndrome with traditional Chinese and western medicine

Ying Lu1,(), Wenning Fu1   

  1. 1. Department of Nephrology, Zhejiang Provincial Tongde Hospital, Zhejiang 310012, China
  • Received:2017-05-15 Published:2017-08-28
  • Corresponding author: Ying Lu
  • About author:
    Corresponding author: Lu Ying, Email:
引用本文:

鲁盈, 傅文宁. 激素抵抗型肾病综合征中西医治疗进展[J]. 中华肾病研究电子杂志, 2017, 06(04): 165-168.

Ying Lu, Wenning Fu. Progress in treatment of steroid-resistant nephrotic syndrome with traditional Chinese and western medicine[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2017, 06(04): 165-168.

激素抵抗肾病综合征(SRNS)是肾脏病临床常见的疑难病症之一,由于常规治疗难以奏效,故属难治性肾病综合征。已有越来越多的学者探索中西医结合治疗方法,以提高临床疗效及缓解长期大剂量免疫抑制剂所带来的副反应。笔者根据自身体会并结合文献复习,提出应注重难治性肾病综合征的规范化治疗,并将中医肾络病理论应用于SRNS的治疗,是可借鉴的方法。

Steroid-resistant nephrotic syndrome (SRNS) is one of the most common and difficult clinical kidney diseases, and is referred to as refractory nephrotic syndrome because the conventional treatment is often ineffective to it. More and more scholars are investigating the integrative Chinese and western medicine therapies in order to improve clinical efficacy and ease side effects caused by long-term high-dose immunosuppressive agents. According to their own experience and the literature review, the authors proposed that attention should be paid to the standardized treatment of refractory NS, as well as the application of kidney collaterals theory from traditional Chinese medicine (TCM) in treatment of SRNS, which is worth using as reference.

[1]
Kemper MJ, Meyer-Jark T, Lilova M, et al.Combined T-and B-ccll activation in childhood steroid-sensitive nephrotic syndrome [J]. Clin Nephrol, 2003, 60(4): 242-247.
[2]
Sinha A, Bagga A. Rituximab therapy in nephrotic syndrome: implications for patients′ management [J]. Nat Rev Nephrol, 2013, 9(3): 154-169.
[3]
Ito S, Kamei K, Ogura M, et al. Survey of rituximab treatment for childhood-onset refractory nephritic syndrome [J]. Pediatr Nephrol, 2013, 28 (2): 257-264.
[4]
Gulati A, Sinha A, Jordan SC, et al. Efficacy and safety of treatment with rituximab for difficult steroid-resistant and-dependent nephrotic syndrome: multicentric report [J]. Clin J Am Soc Nephrol, 2010, 5(12): 2207-2212.
[5]
Prytula A, Iijima K, Kamei K, et al. Rituximab in refractory nephrotic syndrome [J]. Pediatr Nephrol, 2010, 25(3): 461-468.
[6]
Fernandez FG, Segarra A, Gonzalez E, et al. Rituximab treatment of adult patients with steroid -resistant focal segmental glomerulosclerosis [J] . Clin J Am Soc Nephrol, 2009,4(8): 1317-1323.
[7]
Bomback AS, Derebail VK, McGregor JG, et al. Rituximab therapy for membranous nephropathy: a systematic review [J]. Clin J Am Soc Nephrol, 2009, 4(4): 734-744.
[8]
Mallat SG, Itani HS, Abou-Mrad RM. Rituximab use in adult primary glomerulopathy: where is the evidence? [J]. Ther Clin Risk Manag, 2016, 29(12): 1317-1327.
[9]
Trachtman H, Fervenza FC, Gipson DS, et al. A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis [J]. Kidney Int, 2011, 79(11): 1236-1243.
[10]
Ashraf S, Gee HY, Woerner S, et al. ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption [J]. J Clin Invest, 2013, 123(12): 5179-5189.
[11]
Korkmaz E, Lipska-Ziętkiewicz BS, Boyer O, et al. ADCK4-associated glomerulopathy causes adolescence-onset FSGS [J]. J Am Soc Nephrol, 2016, 27(1): 63-68.
[12]
Muso E, Mune M, Hirano T, et al. Immediate therapeutic efficacy of low-density lipoprotein apheresis for drug-resistant nephrotic syndrome: evidence from the short-term results from the POLARIS Study [J]. Clin Exp Nephrol, 2015, 19(3): 379-386.
[13]
Saleem MA. New developments in steroid-resistant nephrotic syndrome [J]. Pediatr Nephrol, 2013, 28(5): 699-709.
[14]
Hogan J, Mohan P, Gerald B. Diagnostic tests and treatment options in glomerular disease: 2014 update [J]. Am J Kidney Dis, 2014, 63 (4): 656-666.
[15]
高燕翔,张佩青,张琪.张琪教授以"通"为用治疗难治性肾病综合征水肿经验[J].中国中西医结合肾病杂志,2014,15(8): 48-49.
[16]
孟立锋,史伟,吴金玉,等.湿热病邪与难治肾病综合征关系探讨[J].江苏中医药杂志,2013,45(10): 11-13.
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