切换至 "中华医学电子期刊资源库"

中华肾病研究电子杂志 ›› 2020, Vol. 09 ›› Issue (06) : 260 -263. doi: 10.3877/cma.j.issn.2095-3216.2020.06.004

所属专题: 总编推荐 文献

综述

腹膜透析相关性真菌性腹膜炎的防治进展
李忻阳1, 张禹1, 罗佩婷1, 王杨威1,(), 崔文鹏1,()   
  1. 1. 130041 长春,吉林大学第二医院肾病内科
  • 收稿日期:2020-07-11 出版日期:2020-12-28
  • 通信作者: 王杨威, 崔文鹏
  • 基金资助:
    吉林省卫生厅项目(2017Q024、2018FP031)

Progress in the prevention and treatment of peritoneal dialysis-associated fungal peritonitis

Xinyang Li1, Yu Zhang1, Peiting Luo1, Yangwei Wang1,(), Wenpeng Cui1,()   

  1. 1. Department of Nephrology, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
  • Received:2020-07-11 Published:2020-12-28
  • Corresponding author: Yangwei Wang, Wenpeng Cui
  • About author:
    Corresponding author: Cui Wenpeng, Email: ;
    Wang Yangwei, Email:
引用本文:

李忻阳, 张禹, 罗佩婷, 王杨威, 崔文鹏. 腹膜透析相关性真菌性腹膜炎的防治进展[J]. 中华肾病研究电子杂志, 2020, 09(06): 260-263.

Xinyang Li, Yu Zhang, Peiting Luo, Yangwei Wang, Wenpeng Cui. Progress in the prevention and treatment of peritoneal dialysis-associated fungal peritonitis[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2020, 09(06): 260-263.

腹膜透析相关性腹膜炎(peritoneal dialysis-associated peritonitis, PDAP)是导致患者退出腹膜透析的主要原因,其中真菌性腹膜炎(fungal peritonitis, FP)虽然在PDAP中占比少,但其治愈率低,由其导致的技术失败率及PDAP相关死亡率高。然而,至今尚缺乏统一的FP预防及治疗方案。预防FP的药物主要包括制霉菌素与氟康唑,但其用药时机尚未确定。治疗FP主要包括拔除导管和抗真菌药物治疗两个方面。然而,尽管在大多数情况下需要拔除导管,但拔除导管的最佳时间仍然未知。本文结合近年来的重要临床研究,对腹膜透析相关性FP的预防及治疗进行综述。

Peritoneal dialysis-associated peritonitis (PDAP) is the main reason that causes patients to withdraw from peritoneal dialysis. Although fungal peritonitis (FP) accounted for less in PDAP, it had the lowest cure rate, the highest technical failure rate and PDAP-related mortality. However, there is still no unified FP prevention and treatment program. The drugs to prevent FP mainly include nystatin and fluconazole, but the timing of their use has not been determined. Treatment of FP mainly includes catheter removal and antifungal therapy. However, although catheter removal is required in most cases, the optimal time for catheter removal is still unknown. In this paper, the prevention and treatment of peritoneal dialysis-related FP was reviewed in combination with recent important clinical studies.

[1]
Bargman JM, Fredette N, Claire A. Characteristics and outcomes of fungal peritonitis in a modern north American cohort [J]. Perit Dial Int, 2015, 35(1): 78-84.
[2]
Chavada R, Kok J, Hal SV, et al. Seeking clarity within cloudy effluents: differentiating fungal from bacterial peritonitis in peritoneal dialysis patients [J]. PLoS One, 2011, 6(12): e28247.
[3]
Jayanthi GS, Kumar KV, Mallkarjuna HM. Fungal peritonitis in continuous ambulatory peritoneal dialysis: the impact of antifungal prophylaxis on patient and technique outcomes [J]. Indian J Nephrol, 2014, 24(5): 297-301.
[4]
Hu S, Tong R, Bo Y, et al. Fungal peritonitis in peritoneal dialysis: 5-year review from a North China center [J]. Infection, 2019, 47(1): 35-43.
[5]
Verma A, Mothu PN, Kalawat U, et al. Fungal peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients [J]. J Clin Diagn Res, 2018, 12(8): 6-9.
[6]
Auricchio S, Giovenzana ME, Pozzi M, et al. Fungal peritonitis in peritoneal dialysis: a 34-year single centre evaluation [J]. Clin Kidney J, 2018, 11(6): 874-880.
[7]
中国腹膜透析相关感染防治专家组. 腹膜透析相关感染的防治指南 [J]. 中华肾脏病杂志,2018, 34(2): 139-148.
[8]
Fan SL, Nicfhogartaigh C. Response to letter "Gram stain of peritoneal dialysis fluid: the potential of direct policy-determining importance in early diagnosis of fungal peritonitis" [J]. Perit Dial Int, 2019, 39(6): 575.
[9]
Chamroensakchai T, Manuprasert W, Puapatanakul P, et al. Serum galactomannan index for the rapid diagnosis of fungal peritonitis in patients with peritoneal dialysis [J]. Kidney Int Rep, 2019, 5(4): 530-534.
[10]
Giacobino J, Montelli AC, Barretti P, et al. Fungal peritonitis in patients undergoing peritoneal dialysis (PD) in Brazil: molecular identification, biofilm production and antifungal susceptibility of the agents [J]. J Med Vet Myco, 2016, 54(7): 725-732.
[11]
García AR, García MP. Aspectos clínicos y microbiológicos de la peritonitis fúngica en diálisis peritoneal [J]. Nefrología, 2009, 29(29): 506-517.
[12]
Szeto CC, Li PKT. Peritoneal dialysis-associated peritonitis [J]. Clin J Am Soc Nephrol, 2019, 14(7): 1100-1105.
[13]
Wong PN, Lo KY, Tong GMW, et al. Prevention of fungal peritonitis with nystatin prophylaxis in patients receiving CAPD [J]. Perit Dial Int, 2007, 27(5): 531-536.
[14]
Restrepo C, Chacon J, Manjarres G. Fungal peritonitis in peritoneal dialysis patients: successful prophylaxis with fluconazole, as demonstrated by prospective randomized control trial [J]. Perit Dial Int, 2010, 30(6): 619-625.
[15]
Lopes K, Rocha A, Rodrigues A, et al. Long-term peritoneal dialysis experience: quality control supports the use of fluconazole to prevent fungal peritonitis [J]. Int J Artif Organs, 2013, 36(7): 484-488.
[16]
Prabhu MV, Subhramanyam SV, Gandhe S, et al. Prophylaxis against fungal peritonitis in CAPD-a single center experience with low-dose fluconazole [J]. Ren Fail, 2010, 32(7): 802-805.
[17]
Li PK, Szeto CC, Piraino B, et al. ISPD peritonitis recommendations: 2016 update on prevention and treatment [J]. Perit Dial Int, 2016, 36(5): 481-508.
[18]
Wong P, Lo K, Tong G, et al. Treatment of fungal peritonitis with a combination of intravenous amphotericin B and oral flucytosine, and delayed catheter replacement in continuous ambulatory peritoneal dialysis [J]. Perit Dial Int, 2008, 28(2): 155-162.
[19]
Pappas PG, Kauffman CA, Anders DR, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America [J]. Clin Infect Dis, 2016, 62: 1-50.
[20]
Ghebremedhin B, Bluemel A, Neumann KH, et al. Peritonitis due to Neosartorya pseudofischeri in an elderly patient undergoing peritoneal dialysis successfully treated with voriconazole [J]. J Med Microbiol, 2009, 58(Pt 5): 678-682.
[21]
Prépost E, Tóth Z, Perlin DS, et al. Efficacy of humanized single large doses of caspofungin on the lethality and fungal tissue burden in a deeply neutropenic murine model against Candida albicans and Candida dubliniensis [J]. Infect Drug Resist, 2019, 12: 1805-1814.
[22]
Grimaldi D, Daugas E, Mougenot B, et al. Immuno-allergic interstitial nephritis related to fluindione: first biopsy proven cases [J]. Nephrol Dial Transplant, 2006, 21(1): 237.
[23]
Pasqualotto AC, Howard SJ, Moore CB, et al. Flucytosine therapeutic monitoring: 15 years experience from the UK [J]. J Antimicrob Chemother, 2007, 59(4): 791-793.
[24]
Andes D, Pascual A, Marchetti O. Antifungal therapeutic drug monitoring: established and emerging indications [J]. Antimicrob Agents Chemother, 2009, 53(1): 24-34.
[25]
Liu YL, Huang CC, Kao MT. Residual renal function predicts outcome of fungal peritonitis in peritoneal dialysis patients [J]. Perit Dial Int, 2006, 26(3): 407-409.
[26]
Chang TI, Kim HW, Park JT, et al. Early catheter removal improves patient survival in peritoneal dialysis patients with fungal peritonitis: results of ninety-four episodes of fungal peritonitis at a single center [J]. Perit Dial Int, 2011, 31(1): 60-66.
[1] 衣晓丽, 胡沙沙, 张彦. HER-2低表达对乳腺癌新辅助治疗疗效及预后的影响[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 340-346.
[2] 谭巧, 苏小涵, 侯令密, 黎君彦, 邓世山. 乳腺髓样癌的诊治进展[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 366-368.
[3] 杨小菁, 姜瑞瑞, 石玉香, 王静静, 李长天. 乳腺孤立性纤维性肿瘤一例[J]. 中华乳腺病杂志(电子版), 2023, 17(06): 375-377.
[4] 张伟. 牙及牙槽外科:舒适治疗的先锋[J]. 中华口腔医学研究杂志(电子版), 2023, 17(06): 386-388.
[5] 王得晨, 杨康, 杨自杰, 归明彬, 屈莲平, 张小凤, 高峰. 结直肠癌微卫星稳定状态和程序性死亡、吲哚胺2,3-双加氧酶关系的研究进展[J]. 中华普通外科学文献(电子版), 2023, 17(06): 462-465.
[6] 彭旭, 邵永孚, 李铎, 邹瑞, 邢贞明. 结肠肝曲癌的诊断和外科治疗[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 108-110.
[7] 马伟强, 马斌林, 吴中语, 张莹. microRNA在三阴性乳腺癌进展中发挥的作用[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 111-114.
[8] 张海涛, 康婵娟, 翟静洁. 胰管支架置入治疗急性胆源性胰腺炎效果观察[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 654-657.
[9] 杨雪, 张伟, 尚培中, 宋创业, 尚丹丹, 张蔚. 胆囊十二指肠瘘结石经瘘口排出后自愈一例报道[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 707-708.
[10] 孔博, 张璟, 吕珂. 超声技术在复杂腹壁疝诊治中的作用[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(06): 670-673.
[11] 姜明, 罗锐, 龙成超. 闭孔疝的诊断与治疗:10年73例患者诊疗经验总结[J]. 中华疝和腹壁外科杂志(电子版), 2023, 17(06): 706-710.
[12] 陆志峰, 周佳佳, 梁舒. 虚拟现实技术在治疗弱视中的临床应用研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(08): 891-895.
[13] 李田, 徐洪, 刘和亮. 尘肺病的相关研究进展[J]. 中华临床医师杂志(电子版), 2023, 17(08): 900-905.
[14] 岳瑞雪, 孔令欣, 郝鑫, 杨进强, 韩猛, 崔国忠, 王建军, 张志生, 孔凡庭, 张维, 何文博, 李现桥, 周新平, 徐东宏, 胡崇珠. 乳腺癌HER2蛋白表达水平预测新辅助治疗疗效的真实世界研究[J]. 中华临床医师杂志(电子版), 2023, 17(07): 765-770.
[15] 符梅沙, 周玉华, 李慧, 薛春颜. 淋巴细胞免疫治疗对复发性流产患者外周血T淋巴细胞亚群分布与PD1/PD-L1表达的影响及意义[J]. 中华临床医师杂志(电子版), 2023, 17(06): 726-730.
阅读次数
全文


摘要