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中华肾病研究电子杂志 ›› 2021, Vol. 10 ›› Issue (05) : 274 -277. doi: 10.3877/cma.j.issn.2095-3216.2021.05.007

综述

局部枸橼酸抗凝在危重症患儿连续性肾脏替代治疗中的应用进展
朱利娟1, 张卉卉1, 纪明慧1, 邓芳1,()   
  1. 1. 230051 合肥,安徽省儿童医院肾内科
  • 收稿日期:2021-06-24 出版日期:2021-10-20
  • 通信作者: 邓芳
  • 基金资助:
    2020年安徽省重点研究与开发计划立项项目(202004j07020028)

Progress in the application of topical citrate anticoagulation in the continuous renal replacement therapy for critically ill children

Lijuan Zhu1, Huihui Zhang1, Minghui Ji1, Fang Deng1,()   

  1. 1. Department of Nephrology, Anhui Provincial Children′s Hospital, Hefei 230051, Anhui Province, China
  • Received:2021-06-24 Published:2021-10-20
  • Corresponding author: Fang Deng
引用本文:

朱利娟, 张卉卉, 纪明慧, 邓芳. 局部枸橼酸抗凝在危重症患儿连续性肾脏替代治疗中的应用进展[J/OL]. 中华肾病研究电子杂志, 2021, 10(05): 274-277.

Lijuan Zhu, Huihui Zhang, Minghui Ji, Fang Deng. Progress in the application of topical citrate anticoagulation in the continuous renal replacement therapy for critically ill children[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2021, 10(05): 274-277.

在成人连续性肾脏替代治疗(CRRT)中,枸橼酸钠作为抗凝剂优于肝素,但其潜在的不利影响以及在儿童危重症的CRRT中的应用数据有限。本文从局部枸橼酸抗凝的原理及优势、临床应用效果、安全性验证、临床实施方案、临床监测手段、并发症等方面,对国内外儿童危重症的CRRT中进行局部枸橼酸抗凝的相关研究进行了综述。

Sodium citrate is superior to heparin as an anticoagulant in the continuous renal replacement therapy (CRRT) of adults. However, there are limited data on its potential adverse effects and its use in CRRT for critically ill children. This article reviewed the relevant researches on application of topical citrate anticoagulation in CRRT for critically ill children at home and abroad, including the topical citrate anticoagulation′s principles and advantages, efficacy and safety, implementation plans, monitoring methods, and complications, etc.

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