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中华肾病研究电子杂志 ›› 2022, Vol. 11 ›› Issue (02) : 104 -108. doi: 10.3877/cma.j.issn.2095-3216.2022.02.010

综述

抗中性粒细胞胞浆抗体相关性血管炎肾损害的免疫炎症机制研究进展
陈艺勤1, 胡晓璇2, 侯海晶2, 古月瑜2,(), 刘旭生2, 卢富华2,()   
  1. 1. 510405 广州中医药大学第二临床医学院;510120 广州中医药大学第二附属医院(广东省中医院)肾病科
    2. 510120 广州中医药大学第二附属医院(广东省中医院)肾病科
  • 收稿日期:2021-08-10 出版日期:2022-04-28
  • 通信作者: 古月瑜, 卢富华
  • 基金资助:
    国家中医药行业科研专项(201407005); 国家自然科学基金(81903956)

Research progress on the inflammatory and immune mechanisms of renal damage in anti-neutrophil cytoplasmic antibody-associated vasculitis

Yiqin Chen1, Xiaoxuan Hu2, Haijing Hou2, Yueyu Gu2,(), Xusheng Liu2, Fuhua Lu2,()   

  1. 1. Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510405; Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120; Guangdong Province, China
    2. Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120; Guangdong Province, China
  • Received:2021-08-10 Published:2022-04-28
  • Corresponding author: Yueyu Gu, Fuhua Lu
引用本文:

陈艺勤, 胡晓璇, 侯海晶, 古月瑜, 刘旭生, 卢富华. 抗中性粒细胞胞浆抗体相关性血管炎肾损害的免疫炎症机制研究进展[J]. 中华肾病研究电子杂志, 2022, 11(02): 104-108.

Yiqin Chen, Xiaoxuan Hu, Haijing Hou, Yueyu Gu, Xusheng Liu, Fuhua Lu. Research progress on the inflammatory and immune mechanisms of renal damage in anti-neutrophil cytoplasmic antibody-associated vasculitis[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2022, 11(02): 104-108.

抗中性粒细胞胞浆抗体相关性血管炎(AAV)是全身性的自身免疫性疾病,最常累及肾脏微小血管,造成肾小球、肾小动脉的炎症、坏死、肉芽肿浸润,从而导致AAV肾损害。AAV肾损害的发病机制十分复杂,迄今尚未完全明确,其最突出的病理特征即炎症,涉及激活中性粒细胞、补体旁路途径、其它免疫细胞相互作用等。本文就AAV肾损害的免疫炎症机制研究进展进行综述。

Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a systemic autoimmune disease that most often involves small blood vessels in the kidneys, causing inflammation, necrosis, and granulomatous infiltration of glomeruli and arterioles, resulting in the renal damage in AAV. The pathogenesis of renal damage in AAV is very complex and has not yet been fully elucidated, the most prominent pathological feature of which is inflammation involving activation of neutrophils, the alternative pathway of complement, and the interaction of other immune cells. This article reviewed research progress on the inflammatory and immune mechanisms of renal damage in AAV.

图1 ANCA相关性炎症对肾脏组织的损伤机制和病理表现注:Th17:辅助性T细胞17;IFN-γ:γ干扰素;MHC-Ⅰ:major histocompatibility complex class Ⅰ,主要组织相容性复合体Ⅰ;ROS:reactive oxygen species,活性氧
图2 炎症相关免疫细胞调控与AAV肾损害示意图注:BAFF:B cell activation factor,B细胞刺激因子;TNF-α:肿瘤坏死因子α;TGF-β:转化生长因子β;TLRs:Toll样受体;ICAM-1:细胞间粘附分子1;MPO:髓过氧化物酶;PR3:蛋白酶3;IL-6、IL-7、IL-1β和IL-16:白介素家族成员
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