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中华肾病研究电子杂志 ›› 2023, Vol. 12 ›› Issue (02) : 101 -104. doi: 10.3877/cma.j.issn.2095-3216.2023.02.008

综述

罗沙司他在炎症反应中的作用研究进展
王星月1, 舒亮辉1, 朝亚1,()   
  1. 1. 214044 苏州大学附属无锡市第九人民医院肾内科
  • 收稿日期:2021-08-23 出版日期:2023-04-28
  • 通信作者: 朝亚
  • 基金资助:
    无锡市卫健委青年科研项目(Q201753)

Progress of research on the role of roxadustat in inflammatory reaction

Xingyue Wang1, Lianghui Shu1, Ya Chao1,()   

  1. 1. Department of Nephrology, Wuxi Ninth People′s Hospital Affiliated to Suzhou University, Wuxi 214044, Jiangsu Province, China
  • Received:2021-08-23 Published:2023-04-28
  • Corresponding author: Ya Chao
引用本文:

王星月, 舒亮辉, 朝亚. 罗沙司他在炎症反应中的作用研究进展[J]. 中华肾病研究电子杂志, 2023, 12(02): 101-104.

Xingyue Wang, Lianghui Shu, Ya Chao. Progress of research on the role of roxadustat in inflammatory reaction[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2023, 12(02): 101-104.

罗沙司他是一种口服的缺氧诱导因子(HIF)脯氨酰羟化酶的抑制剂,可刺激红细胞生成并改善铁代谢,目前主要用于治疗肾性贫血。已有研究发现,罗沙司他通过稳定HIF表达,还可以调节人体的免疫反应和急、慢性炎症反应。本文综述了近年来有关罗沙司他在炎症反应中的作用与机制研究进展,为其临床应用提供参考。

Roxadustat is an oral inhibitor for the hypoxia-inducible factor (HIF) proline hydroxylase, and can stimulate erythropoiesis and improve iron metabolism, and has currently been mainly used to treat renal anemia. Studies have found that roxadustat can also regulate the immune response as well as acute and chronic inflammatory reaction by stabilizing the expression of HIF. This article reviewed the progress of research on the role and mechanism of roxadustat in inflammatory reaction in recent years in order to provide reference for its clinical application.

图1 罗沙司他通过调节缺氧诱导因子-1α稳定性介导炎症反应注:HIF-1α:缺氧诱导因子-1α;PHD:脯氨酸羟化酶;Nrf2:核因子E2相关因子2; NF-κB:核因子κB; ROS:活性氧;正常状态下PHD羟基化HIF-1α并促使其降解,而在缺氧或罗沙司他作用下HIF-1α可影响Nrf2信号通路、NF-κB通路、ROS及免疫细胞等进一步调节炎症反应
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