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中华肾病研究电子杂志 ›› 2026, Vol. 15 ›› Issue (03) : 176 -179. doi: 10.3877/cma.j.issn.2095-3216.2026.03.010

病例报告

双基因敲除猪-猕猴异种肾移植围手术期监测一例
陈训1,2, 陈健文2, 孙玺钧2, 周亮3, 周佳3, 潘登科4, 杨洪吉5, 谢雨宣6, 杨沛东3, 李清刚2,(), 陈香美1,2,()   
  1. 1510006 广东药科大学
    2100853 北京,解放军总医院肾脏病医学部、肾脏疾病全国重点实验室、国家慢性肾病临床医学研究中心、重症肾脏疾病器械与中西医药物研发北京市重点实验室、数智中医泛血管疾病防治北京市重点实验室、国家中医药管理局高水平中医药重点学科(zyyzdxk-2023310)
    3610212 成都,四川省医学科学院·四川省人民医院实验动物研究所
    4610041 成都,中科奥格生物科技有限公司
    5610072 成都,四川省医学科学院·四川省人民医院器官移植中心
    6临床免疫转化四川省重点实验室
  • 收稿日期:2026-01-06 出版日期:2026-06-28
  • 通信作者: 李清刚, 陈香美

Perioperative monitoring of two-gene-knockout pig-to-macaque renal xenotransplantation: a case report

Xun Chen, Jianwen Chen, Xijun Sun   

  • Received:2026-01-06 Published:2026-06-28
引用本文:

陈训, 陈健文, 孙玺钧, 周亮, 周佳, 潘登科, 杨洪吉, 谢雨宣, 杨沛东, 李清刚, 陈香美. 双基因敲除猪-猕猴异种肾移植围手术期监测一例[J/OL]. 中华肾病研究电子杂志, 2026, 15(03): 176-179.

Xun Chen, Jianwen Chen, Xijun Sun. Perioperative monitoring of two-gene-knockout pig-to-macaque renal xenotransplantation: a case report[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2026, 15(03): 176-179.

图1 移植供受体及移植肾的动态变化过程注:A:受体猕猴术前状态;B:供体基因编辑猪术前状态;C:供肾切取前状态;D:异种肾移植术后恢复血流灌注后;E:实验终点肾脏状态;F:解剖后肾脏状态;G:终末剖检所见肠道出血
图2 肾脏超声检查及阻力指数注:A:术后第1天超声检查结果;B:术后第2天超声检查结果;C:术后第3天超声检查结果;D:术后第9天超声检查结果;E:术后第10天超声检查结果;F:术后第11天超声检查结果;G:超声阻力指数动态变化
图3 受体移植前后检验指标动态变化过程注:A:术后血清肌酐变化;B:术后血红蛋白变化;C:术后血小板计数变化;D:术后红细胞计数变化;E:术后K变化;F:术后球蛋白变化;G:术后丙氨酸氨基转移酶变化;H:术后γ-谷氨酰基转移酶变化;I:术后天冬氨酸氨基转移酶变化
图4 受体术后每日尿液指标及体质量动态变化注:A:受体术后尿量变化;B:受体术后体质量变化
图5 肾脏异种移植11 d后的组织病理学改变注:A:苏木精-伊红染色染色×400;B:过碘酸-希夫染色×400
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