mircroRNA-mediated tubularinterstitial fibrosis in chronic kidney disease

doi:10.3877/cma.j.issn.2095-3216.2012.01.010

Abstract

Abstract:

Chronic kidney disease has been a severe public problem in China. Renal fibrosis is the final outcome for progressive chronic kidney disease. MicroRNAs (miRNAs, miR) are small, noncoding RNAs with about 22 nucleotides, which has proved to play a general role in kidney development and physiological functions. Reports showed that series of miRNA took part in mediating the process of tubular epithelial-mesenchymal transition, leading to renal fibrosis. MiRNA could be a potential therapeutic target for early chronic kidney disease.

Key words: Kidney diseases, Fibrosis, MicroRNAs, Epithelial-mesenchymal transition

Feng WEN, Guo-chun CHEN, Fu-you LIU. mircroRNA-mediated tubularinterstitial fibrosis in chronic kidney disease[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2012, 01(01): 41-44.

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