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Chinese Journal of Kidney Disease Investigation(Electronic Edition) ›› 2012, Vol. 01 ›› Issue (02): 94-97. doi: 10.3877/cma.j.issn.2095-3216.2012.02.007

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Treatment for anti-glomerular basement membrane nephritis

Guang-yi LIU1, Zhao HU1,()   

  1. 1.Renal Division, Qilu Hospital of Shandong University, Jinan 250012, China
  • Received:2012-11-08 Online:2012-12-18 Published:2024-12-06
  • Contact: Zhao HU

Abstract:

The main manifestations of anti-glomerular basement membrane (GBM) nephritis include rapid progressive, refractory glomerulonephritis with or without severe pulmonary hemorrhage,with low survival rates. We summarized the incidence, mechanisms, treatment strategies and prognostic factors of anti-GBM nephritis, under a comprehensive analysis of the latest suggests from Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. We concluded that methyl prednisolone and cyclophosphamide therapy combined with plasma exchange was the first-line therapy for anti-GBM nephritis. Although the survival rate has been greatly increased, the kidney survival rate was still low.Early diagnosis, early intensive treatment was important.

Key words: Anti-glomerular basement membrane nephritis, Treatment

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