The effect of microinflammation on serum ferritin and transferin saturation in maintenance hemodialysis patients

doi:10.3877/cma.j.issn.2095-3216.2013.01.007

Abstract

Abstract:

Objective

To explore the effect of microinflammation on serum ferritin (SF) and transferin saturation (TSAT) in maintenance hemodialysis patients.

Methods

One hundred and fiftyeight cases of maintenance hemodialysis were enrolled, including 97 male and 60 female cases with an average age of 57.9±16.6 years. Case inclusion criteria: (1) regular hemodialysis for more than 6 months;(2) Any age and gender; (3) no bleeding or blood transfusion events within 3 months; (4) SF≥200 μg/ L.Case exclusion criteria: (1) any serious infections; (2) severe malnutrition; (3) severe heart failure;(4) active systemic diseases. The patients were divided into group A (CRP≤8 mg/L) and group B (CRP ＞8 mg/L) according to the C-reactive protein (CRP) level. The differences of serum ferrum (Fe), TSAT,SF and hemoglobin (Hb) were compared between the two groups by t test. According to the SF level, the patients were also divided into group 1 (SF ＜ 500 μg/L) and group 2 (SF≥500 μg/L) between which the differences of CRP and Hb were compared by t test. The correlation between CRP and Fe, TSAT, SF, or Hb in all patients was analyzed by Pearson correlation analysis.

Results

(1) When compared with group B,group A showed lower level of SF but higher levels of TSAT, Fe, and Hb (P ＜ 0.05). (2) When compared with group 1, group 2 showed significantly higher level of CRP (P＜ 0.05). There was no significant difference in Hb between (t = 1.524, P = 0.052) group1 and group2 (P ＞ 0.05). (3) Pearson correlation analysis showed that Fe, TSAT, and Hb all had a negative correlation with CRP.

Conclusion

The levels of SF, TSAT, Fe, and Hb are constantly affected by chronic inflammation in maintenance hemodialysis patients. Therefore, the combination tests of SF, TSAT and CRP may favor the correct assessment of ferrum metabolism state.

Key words: C-reactive protein, Renal anemia, Serum ferritin, Transferrin saturation, Hemoglobin

Xiao-li MA, Xue-feng SUN, Xue-ying CAO, Min-xia LI, Zhi-fang MA, Xiang-mei CHEN. The effect of microinflammation on serum ferritin and transferin saturation in maintenance hemodialysis patients[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2013, 02(01): 34-37.

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Figures/Tables 3

组别	例数	年龄（岁， $\bar{x}$ ±s）	男女比例	透析龄（年， $\bar{x}$ ±s）	收缩压（mm Hg^a， $\bar{x}$ ±s）	舒张压（mm Hg， $\bar{x}$ ±s）	Kt/V（ $\bar{x}$ ±s）
CRP≤8mg/L组	122	56.6±15.6	75/47	5.72±3.17	136.0±14.4	79.9±10.3	1.51±0.29
CRP＞8mg/L组	36	62.0±19.3	22/14	5.15±2.49	132.3±15.7	76.9±10.0	1.53±0.25
t值		6.782	4.821	3.765	2.876	3.163	1.237
P值		0.069	0.065	0.789	0.826	0.743	0.812
组别	例数	白蛋白(g/L)	血肌酐(μmol/L)	尿素氮(mmol/L)	铁蛋白(μg/L)	转铁蛋白饱和度(%)	血清铁(umol/L)	血红蛋白(g/L)
CRP≤8mg/L组	122	39.7±3.75	928.1±234.5	29.8±6.20	849±447	35.4±13.8	13.2±4.5	114.8±12.0
CRP＞8mg/L组	36	38.0±3.01	822.0±182.3	27.6±3.79	1077±548	26.6±8.4	9.6±3.5	110.2±13.4
t值		15.753	1.254	4.981	-1.908	22.422	3.192	1.616
P值		0.057	0.076	0.784	0.049^b	＜0.001^b	0.002^b	0.047^b

组别	例数	年龄（岁， $\bar{x}$ ±s）	男女比例	透析龄（年， $\bar{x}$ ±s）	收缩压（mm Hg^a， $\bar{x}$ ±s）	舒张压（mm Hg， $\bar{x}$ ±s）	Kt/V（ $\bar{x}$ ±s）
CRP≤8mg/L组	122	56.6±15.6	75/47	5.72±3.17	136.0±14.4	79.9±10.3	1.51±0.29
CRP＞8mg/L组	36	62.0±19.3	22/14	5.15±2.49	132.3±15.7	76.9±10.0	1.53±0.25
t值		6.782	4.821	3.765	2.876	3.163	1.237
P值		0.069	0.065	0.789	0.826	0.743	0.812
组别	例数	白蛋白(g/L)	血肌酐(μmol/L)	尿素氮(mmol/L)	铁蛋白(μg/L)	转铁蛋白饱和度(%)	血清铁(umol/L)	血红蛋白(g/L)
CRP≤8mg/L组	122	39.7±3.75	928.1±234.5	29.8±6.20	849±447	35.4±13.8	13.2±4.5	114.8±12.0
CRP＞8mg/L组	36	38.0±3.01	822.0±182.3	27.6±3.79	1077±548	26.6±8.4	9.6±3.5	110.2±13.4
t值		15.753	1.254	4.981	-1.908	22.422	3.192	1.616
P值		0.057	0.076	0.784	0.049^b	＜0.001^b	0.002^b	0.047^b

组别	例数	年龄（岁， $\bar{x}$ ±s）	男女比例	透析龄（年， $\bar{x}$ ±s）	收缩压（mm Hg^a， $\bar{x}$ ±s）	舒张压（mm Hg， $\bar{x}$ ±s）	Kt/V（ $\bar{x}$ ±s）
SF＜500μg/L组	35	59.3±14.6	21/14	5.18±2.62	135.8±14.8	80.0±8.60	1.50±0.31
SF≥500μg/L组	123	57.5±17.2	76/47	5.70±3.14	135.0±14.8	79.0±10.71	1.52±0.27
t值		4.975	4.864	3.643	2.165	2.673	1.532
P值		0.126	0.063	0.812	0.982	0.852	0.766
组别	例数	白蛋白(g/L)	血肌酐(μmol/L)	尿素氮(mmol/L)	血清铁(μmol/L)	TSAT(%)	CRP(μmol/L)	血红蛋白(g/L)
SF＜500μg/L组	35	40.1±3.02	897.9±271.8	30.0±7.96	11.7±3.82	29.9±9.92	4.94±3.47	116.7±11.2
SF≥500μg/L组	123	39.1±3.80	927.1±226.8	28.9±4.99	12.6±4.68	34.4±13.9	9.22±1.52	112.4±12.3
t值		14.832	1.013	4.289	1.876	12.768	-3.536	1.524
P值		0.078	0.082	0.812	0.125	0.068	＜0.001^b	0.052

组别	例数	年龄（岁， $\bar{x}$ ±s）	男女比例	透析龄（年， $\bar{x}$ ±s）	收缩压（mm Hg^a， $\bar{x}$ ±s）	舒张压（mm Hg， $\bar{x}$ ±s）	Kt/V（ $\bar{x}$ ±s）
SF＜500μg/L组	35	59.3±14.6	21/14	5.18±2.62	135.8±14.8	80.0±8.60	1.50±0.31
SF≥500μg/L组	123	57.5±17.2	76/47	5.70±3.14	135.0±14.8	79.0±10.71	1.52±0.27
t值		4.975	4.864	3.643	2.165	2.673	1.532
P值		0.126	0.063	0.812	0.982	0.852	0.766
组别	例数	白蛋白(g/L)	血肌酐(μmol/L)	尿素氮(mmol/L)	血清铁(μmol/L)	TSAT(%)	CRP(μmol/L)	血红蛋白(g/L)
SF＜500μg/L组	35	40.1±3.02	897.9±271.8	30.0±7.96	11.7±3.82	29.9±9.92	4.94±3.47	116.7±11.2
SF≥500μg/L组	123	39.1±3.80	927.1±226.8	28.9±4.99	12.6±4.68	34.4±13.9	9.22±1.52	112.4±12.3
t值		14.832	1.013	4.289	1.876	12.768	-3.536	1.524
P值		0.078	0.082	0.812	0.125	0.068	＜0.001^b	0.052

检测指标	r值	P值
SF	0.096	0.292
TSAT	-0.205	0.024
Fe	-0.291	0.024
Hb	-0.331	＜0.001

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