Abstract:

Objective

To explore the clinical manifestation, renal pathology and prognosis characteristics in acute renal failure (ARF) caused by lupus nephritis (LN) in male patients.

Methods

Between April, 2003 and June, 2011 29 male LN patients with ARF were retrospectively reviewed for clinical manifestation, renal pathology and prognosis.

Results

Age of the patients were (31.7±11.5)years old (age range 16 - 63), among all the 29 patients, there were 25 young (≤45 years old) and 4 middle-aged (46 - 64) years old. Besides ARF, 26 (89.7%) patients had nephrotic syndrome, and the signs of other organs involvement were found. Renal biopsy was performed in all patients. The pathology results were: 22 patients with class Ⅳ (crescentic glomerulonephritis in 4), 1 patient with classⅤ, 6 patients with classⅣ and Ⅴ. The main treatment was glucocorticoids in combination with cyclophosphamide. Follow up was available in 21 patients for a period of 6 - 68 months until December, 2011. There was 1 patient died, 57.1% of the patients developed chronic renal failure and renal function recovered to normal in 42.9% of the patients.

Conclusion

There were more young patients in male LN patients with ARF. Most of them with nephrotic syndrome, and more with severe renal pathologic classification; but in 42.9% of the patients, the renal function recovered.

Key words: Acute renal failure, Lupus nephritis, Male, Renal pathology