Emphasis on clinical and basic research of acute kidney injury

doi:10.3877/cma.j.issn.2095-3216.2013.03.001

Abstract

Abstract:

Acute kidney injury (AKI) is a common clinical acute critical illness. The incidence and mortality of AKI in hospitalized patients is increasing year by year, which consumes large amounts of health care resources. How to prevent the occurrence and development of AKI has now become the focus and hotspots of the nephrology research work. Emphasis should be paid on basic researches of not only the epidemiological characteristics including AKI disease spectrum of etiology, etc., but also the pathogenesis,early diagnosis, and clinical treatment. Besides, evidence-based national multi-centeral, large sample, and prospective medical research on AKI prevention and treatment should be conducted. These will be of great significance on the prevention of and prognosis of AKI. In this paper, we have made a review and outlook on current progress of domestic and international study of the pathogenesis as well as the status of diagnosis and treatment of AKI.

Key words: Acute kidney injury, Definition, Biomarker, Treatment, Progress

Xiang-mei CHEN, Zhe FENG. Emphasis on clinical and basic research of acute kidney injury[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2013, 02(03): 110-114.

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References 25

1	Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury [J]. Kidney int, 2012, Suppl 2: 19-36.
2	Waikar SS, Curhan GC, Wald R, et al. Declining mortality in patients with acute renal failure, 1988 to 2002 [J]. J Am Soc Nephrol, 2006, 17(4): 1143-1150.
3	Ali T, Khan I, Simpson W, et al. Incidence and outcomes in acute kidney injury: A comprehensive population-based study [J]. J Am Soc Nephrol, 2007, 18(4): 1292-1298.
4	Fang Y, Ding XQ, Zhong YH, et al. Acute Kidney Injury in a Chinese Hospitalized Population [J]. Blood Purif, 2010, 30(2): 120-126.
5	Venkatachalam MA, Weinberg JM. The tubule pathology of septic acute kidney injury: a neglected area of research comes of age [J].Kidney Int, 2012, 81(4): 338-340.
6	Wang Z, Holthoff JH, Seely KA, et al. Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure and acute kidney injury [J]. Am J Pathol, 2012, 180(2): 505-516.
7	Jacobs R, Honore PM, Joannes-Boyau O, et al. Septic acute kidney injury: the culprit is inflammatory apoptosis rather than ischemic necrosis [J]. Blood Purif, 2011, 32(4): 262-265.
8	Hoste EA, Clermont G, Kersten A, et al. RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis [J]. Crit Care, 2006, 10(3): R73.
9	Payen D, de Pont AC, Sakr Y, et al. A positive fluid balance is associated with a worse outcome in patients with acute renal failure [J]. Crit Care, 2008, 12(3): R74.
10	Bouchard J, Soroko SB, Chertow GM, et al. Fluid accumulation,survival and recovery of kidney function in critically ill patients with acute kidney injury [J]. Kidney Int, 2009, 76(4): 422-427.
11	Schachinger H, Klarhofer M, Linder L, et al. Angiotensin II decreases the renal MRI blood oxygenation level-dependent signal [J]. Hypertension, 2006, 47(6): 1062-1066.
12	Deng AH, Miracle CM, Suarez JM, et al. Oxygen consumption in the kidney: effects of nitric oxide synthase isoforms and angiotensin II [J]. Kidney Int, 2005, 68(2): 723-730.
13	Aravindan N, Aravindan S, Riedel BJ, et al. Furosemide prevents apoptosis and associated gene expression in a rat model of surgical ischemic acute renal failure [J]. Renal Fail, 2007, 29(4):399-407.
14	Briguori C, Visconti G, Focaccio A, et al. Renal insufficiency after contrast media administration trial II (REMEDIAL II) renal guard system in high-risk patients for contrast-induced acute kidney injury [J]. Circulation, 2011, 124(11): 1260-1269.
15	Mehta RL, Pascual MT, Soroko S, et al. Diuretics, mortality, and nonrecovery of renal function in acute renal [J]. JAMA, 2002,288(20): 2547-2553.
16	Uchino S, Doig GS, Bellomo R, et al. Diuretics and mortality in acute renal failure [J]. Crit Care Med, 2004, 32(8): 1669-1677.
17	Ho KM, Sheridan DJ. Meta-analysis of frusemide to prevent or treat acute renal failure [J]. BMJ, 2006, 333(7565): 420-423.
18	Sampath S, Moran JL, Graham PL, et al. The efficacy of loop diuretics in acute renal failure: assessment using bayesian evidence synthesis techniques [J]. Crit Care Med, 2007, 35(11):2516-2524.
19	Karvellas CJ, Farhat MR, Sajjad I, et al. A comparison of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury: a systematic review and metaanalysis [J]. Crit Care, 2011, 15(1): R72.
20	Goldstein SL, Somers MJG, Baum MA, et al. Pediatric patients with multi-organ dysfunction syndrome receiving continuous renal replacement therapy [J]. Kidney Int, 2005, 67(2): 653-658.
21	Sutherland SM, Zappitelli M, Alexander SR, et al. Fluid overload and mortality in children receiving continuous renal replacement therapy: the prospective pediatric continuous renal replacement therapy registry [J]. Am J Kidney Dis, 2010, 55(2): 316-325.
22	Manns B, Doig CJ, Lee H, et al. Cost of acute renal failure requiring dialysis in the intensive care unit: Clinical and resource implications of renal recovery [J]. Crit Care Med, 2003, 31(2):449-455.
23	Cho KC, Himmelfarb J, Paganini E, et al. Survival by dialysis modality in critically ill patients with acute kidney injury [J]. J Am Soc Nephrol, 2006, 17(11): 3132-3138.
24	Jun M, Lambers Heerspink HJ, Ninomiya T, et al. Intensities of renal replacement therapy in acute kidney injury: a systematic review and Meta-analysis [J]. Clin J Am Soc Nephro, 2010, 5(6):956-963.
25	Van Wert R, Friedrich JO, Scales DC, et al. High-dose renal replacement therapy for acute kidney injury: Systematic review and meta-analysis [J]. Crit Care Med, 2010, 38(5): 1360-1369.

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