Abstract:

Attention to prevention and treatment of cardiovascular and cerebrovascular co-morbidities in patients with chronic kidney disease (CKD). CCDs are significant predictors of progression and poor outcomes of CKD. Meanwhile, reduced glomerular filtration rate and albuminuria are also independent risk factors of development and aggravation of CCDs. However, CCDs are obviously underdiagnosed and undertreated in patients with CKD. Renal impairment often influenced the efficacy of CCDs treatment, and the complex relationship between CKD and CCDs is recognized insufficiently by the clinicians. Now, we should make clear the interplay between CKD and CCDs from clinical phenomenon and pathological mechanisms. Further researches are needed to investigate early detection and unknown pathophysiological mechanisms of CCDs in patients with CKD. It can be believed that new therapeutic interventions will be found for CDDs in patients with CKD by the future research.

Key words: Chronic kidney disease, Cardiovascular disease, Cerebrovascular disease, Co-morbidity, Intervention strategy