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Chinese Journal of Kidney Disease Investigation(Electronic Edition) ›› 2015, Vol. 04 ›› Issue (06): 277-280. doi: 10.3877/cma.j.issn.2095-3216.2015.06.001

Special Issue:

• Editorial •     Next Articles

Immunosuppressive agents in treatment for idiopathic membranous nephropathy

Weiming Wang1,(), Lili Xu1   

  1. 1. Department of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai Jiaotong University Institute of Kidney Diseases, Shanghai 200025, China
  • Online:2015-12-28 Published:2015-12-28
  • Contact: Weiming Wang
  • About author:
    Corresponding author: Wang Weiming, Email:

Abstract:

Idiopathic membranous nephropathy (IMN) is one of the common types of primary glomerulonephritis in our country, and mainly manifests symptoms and signs of nephrotic syndrome, including massive proteinuria, hypoproteinemia, edema, and hyperlipidemia, etc. Individual prognosis has great differences. Immunosuppressive agent is one of the main therapeutic medicines for IMN, among which the glucocorticoids, alkylating agents (cyclophosphamide/chlorambucil), calcineurin inhibitors (cyclosporine/tacrolimus), and Tripterygium wilfordii, etc, play important roles in the treatment of IMN. Recent studies showed that new immunosuppressive agents, such as rituximab, mycophenolate mofetil, leflunomide, and adrenocorticotropic hormone also had certain prospects in the treatment of IMN.

Key words: Idiopathic membranous nephropathy, Immunosuppressive agent, Treatment

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