Under the physiological condition, human daily production and excretion of uric acid are maintained basically at a dynamic balance.When serum uric acid level is higher than 420 μmol/L in men or 360 μmol/L in women, there is hyperuricemia. With the change of life style, diet structure, and increase of aging population, the incidence of hyperuricemia is increasing year by year. Recently more and more researches have indicated that hyperuricemia is closely related to chronic kidney disease (CKD). Uric acid is the poorly soluble circulating end product of the purine nucleotide metabolism. A reduction in the glomerular filtration rate (GFR) contributes to hyperuricemia. Long- term hyperuricemia can lead to progressive deterioration of renal function, increasing the risk of cardiovascular disease in patients with increased mortality. It is important to investigate the management for CKD patients with hyperuricemia. There are expert consensus and guidelines for diagnosis and treatment of the hyperuricemia. The basis of treatment is improving the life style, and the core of treatment are early intervention and comprehensive management.