To investigate the clinical-pathological features and related risk factors in IgA nephropathy patients with hyperuricemia.

Between January 2010 and July 2015, a total of 188 IgA nephropathy patients were recruited, who were diagnosed IgA nephropathy by renal biopsy in the Second Hospital of Shanxi Medical University, and divided into high uric acid group and normal uric acid group. Collected were general data, urine protein amount, renal function, and other clinical biochemical as well as pathological indicators; and Oxford classification system was applied for the renal histopathology. Clinical manifestation and renal pathology features were analyzed for the two groups; and multiple regression statistical methods were applied to analyze the influencing factors for hyperuricemia occurrence. And other data were statistically analyzed with the SPSS13.0 software.

Of the 188 IgA nephropathy patients, there were 42 patients with hyperuricemia (22.34%), among whom there were 36 males and 6 females; and compared with the normal uric acid group consisting of 61 males and 85 females, the high uric acid group consisted of more male patients (χ²=25.2, P<0.001). The Oxford classification system analysis showed that in the IgA nephropathy patients with hyperuricemia M1E1S0T0 was predominant. In the high uric acid group, tubulointerstitial lesions were more severe than those of the normal uric acid group (χ²=5.056, P=0.025), and there were more IgA deposits on capillary loops than in the normal uric acid group (χ²=44.69, P<0.001). In the IgA nephropathy patients with hyperuricemia, the relevant factors were male, obesity, hypertriglyceridemia, and deposition of IgA on the capillary loops.

The risk factors for hyperuricemia in IgA nephropathy consists of maleness, obesity and hypertriglyceridemia, as well as deposition of IgA on the capillary loops.