Inflammation and IgA nephropathy

doi:10.3877/cma.j.issn.2095-3216.2016.05.005

Abstract

Abstract:

IgA nephropathy (IgAN)is the most common primary glomerular disease worldwide, and also one of the common causes for end-stage renal disease. IgAN is now considered to be a kind of autoimmune-mediated inflammatory disease. However, the pathogenesis of IgAN is still unclear. Previous basic research and clinical observation have shown that inflammation is associated with the pathogenesis, aggravation, and progression of IgAN. This article will discuss the relationship between inflammation and the pathogenesis of IgAN, and further discuss the effect of inflammation intervention on the clinical features and prognosis of IgAN.

Key words: IgA nephropathy, Inflammation, Pathogenesis, Therapy

Guisen Li, Changwei Wu. Inflammation and IgA nephropathy[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2016, 05(05): 209-213.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhsbyjdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-3216.2016.05.005

https://zhsbyjdzzz.cma-cmc.com.cn/EN/Y2016/V05/I05/209

References 49

1	Wyatt RJ, Julian BA. IgA nephropathy [J]. N Engl J Med, 2013, 368(25):2402-2414.
2	D′Amico G. The commonest glomerulonephritis in the world: IgA nephropathy [J]. Q J Med, 1987, 64(245):709-727.
3	Coppo R, Amore A, Hogg R, et al. Idiopathic nephropathy with IgA deposits [J]. Pediatr Nephrol, 2000, 15(1-2):139-150.
4	Bene MC, Hurault De Ligny B, Kessler M, et al. Confirmation of tonsillar anomalies in IgA nephropathy: a multicenter study [J]. Nephron, 1991, 58(4):425-428.
5	Maarten W, Glenn M, Philip A, et al. Brenner & Rector′s The Kindey [M]. 9th ed. Philadelphia: WB Saunders Company, 2011: 1145-1148.
6	Xie Y, Chen X, Nishi S, et al. Relationship between tonsils and IgA nephropathy as well as indications of tonsillectomy [J]. Kidney Int, 2004, 65(4):1135-1144.
7	Rekola S, Bergstrand A, Bucht H, et al. Are beta-haemolytic streptococci involved in the pathogenesis of mesangial IgA-nephropathy? [J]. Proc Eur Dial Transplant Assoc Eur Ren Assoc, 1985, 21:698-702.
8	Nagasawa Y, Iio K, Fukuda S, et al. Periodontal disease bacteria specific to tonsil in IgA nephropathy patients predicts the remission by the treatment [J]. PLoS One, 2014, 9(1):e81636.
9	Liu H, Peng Y, Liu F, et al. Expression of IgA class switching gene in tonsillar mononuclear cells in patients with IgA nephropathy [J]. Inflamm Res, 2011, 60(9):869-878.
10	Endo Y, Hara M. Glomerular IgA deposition in pulmonary diseases [J]. Kidney Int, 1986, 29(2):557-562.
11	Naito T, Kida H, Yokoyama H, et al. A case of diffuse panbronchiolitis (DPB) with benign monoclonal IgA gammopathy and IgA nephropathy with monoclonal IgA deposition [J]. Jpn J Med, 1989, 28(4):503-505.
12	Tossier C, Pilette C, Guilleminault L, et al. Diffuse panbronchiolitis and IgA nephropathy [J]. Am J Respir Crit Care Med, 2014, 189(1):106-109.
13	Rollino C, Vischini G, Coppo R. IgA nephropathy and infections [J]. J Nephrol, 2016, Epub ahead of print.
14	De Angelis M, Montemurno E, Piccolo M, et al. Microbiota and metabolome associated with immunoglobulin A nephropathy (IgAN) [J]. PLoS One, 2014, 9(6):e99006.
15	Welander A, Sundelin B, Fored M, et al. Increased risk of IgA nephropathy among individuals with celiac disease [J]. J Clin Gastroenterol, 2013, 47(8):678-683.
16	Szigeti N, Kovacs T, Degrell P, et al. Secondary IgA-nephropathy in gastroenterological diseases [J]. Orv Hetil, 2007, 148(7):313-318.
17	Rostoker G, Wirquin V, Terzidis H, et al. Mucosal immunity in primary glomerulonephritis. III. Study of intestinal permeability [J]. Nephron, 1993, 63(3):286-290.
18	Davin JC, Forget P, Mahieu PR. Increased intestinal permeability to (51 Cr) EDTA is correlated with IgA immune complex-plasma levels in children with IgA-associated nephropathies [J]. Acta Paediatr Scand, 1988, 77(1):118-124.
19	Kovacs T, Mette H, Per B, et al. Relationship between intestinal permeability and antibodies against food antigens in IgA nephropathy [J]. Orv Hetil, 1996, 137(2):65-69.
20	Rostoker G, Delchier JC, Chaumette MT. Increased intestinal intra-epithelial T lymphocy4tes in primary glomerulonephritis: a role of oral tolerance breakdown in the pathophysiology of human primary glomerulonephritides? [J]. Nephrol Dial Transplant, 2001, 16(3):513-517.
21	McCarthy DD, Kujawa J, Wilson C, et al. Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy [J]. J Clin Invest, 2011, 121(10):3991-4002.
22	Kshirsagar AV, Moss KL, Elter JR, et al. Periodontal disease is associated with renal insufficiency in the Atherosclerosis Risk In Communities (ARIC) study [J]. Am J Kidney Dis, 2005, 45(4):650-657.
23	Hara M, Nemoto T, Hijima T, et al. A case of IgA nephropathy associated with mycosis fungoides that developed into rapidly progressive glomerulonephritis [J]. Clin Nephrol, 2013, 79(2):161-165.
24	Inoue CN, Matsutani S, Ishidoya M, et al. Periodontal and ENT therapy in the treatment of pediatric Henoch-Schonlein purpura and IgA nephropathy [J]. Adv Otorhinolaryngol, 2011, 72:53-56.
25	Suzuki H, Kiryluk K, Novak J, et al. The pathophysiology of IgA nephropathy [J]. J Am Soc Nephrol, 2011, 22(10):1795-1803.
26	Novak J, Julian BA, Mestecky J, et al. Glycosylation of IgA1 and pathogenesis of IgA nephropathy [J]. Semin Immunopathol, 2012, 34(3):365-382.
27	Serino G, Sallustio F, Cox SN, et al. Abnormal miR-148b expression promotes aberrant glycosylation of IgA1 in IgA nephropathy [J]. J Am Soc Nephrol, 2012, 23(5):814-824.
28	Sun Q, Zhang J, Zhou N, et al. DNA methylation in Cosmc promoter region and aberrantly glycosylated IgA1 associated with pediatric IgA nephropathy [J]. PLoS One, 2015, 10(2):e0112305.
29	Qin W, Zhong X, Fan JM, et al. External suppression causes the low expression of the Cosmc gene in IgA nephropathy [J]. Nephrol Dial Transplant, 2008, 23(5):1608-1614.
30	He L, Peng Y, Liu H, et al. Activation of the interleukin-4/signal transducer and activator of transcription 6 signaling pathway and homeodomain-interacting protein kinase 2 production by tonsillar mononuclear cells in IgA nephropathy [J]. Am J Nephrol, 2013, 38(4):321-332.
31	Liu LL, Wang LN, Jiang Y, et al. Tonsillectomy for IgA nephropathy: a meta-analysis [J]. Am J Kidney Dis, 2015, 65(1):80-87.
32	Boyd JK, Cheung CK, Molyneux K, et al. An update on the pathogenesis and treatment of IgA nephropathy [J]. Kidney Int, 2012, 81(9):833-843.
33	van den Wall Bake AW, Daha MR, Evers-Schouten J, et al. Serum IgA and the production of IgA by peripheral blood and bone marrow lymphocytes in patients with primary IgA nephropathy: evidence for the bone marrow as the source of mesangial IgA [J]. Am J Kidney Dis, 1988, 12(5):410-414.
34	Mestecky J, Raska M, Julian BA, et al. IgA nephropathy: molecular mechanisms of the disease [J]. Annu Rev Pathol, 2013, 8:217-240.
35	Robert T, Berthelot L, Cambier A, et al. Molecular insights into the pathogenesis of IgA nephropathy [J]. Trends Mol Med, 2015, 21(12):762-775.
36	Suzuki H, Suzuki Y, Aizawa M, et al. Th1 polarization in murine IgA nephropathy directed by bone marrow-derived cells [J]. Kidney Int, 2007, 72(3):319-327.
37	Hurtado A, Johnson RJ. Hygiene hypothesis and prevalence of glomerulonephritis [J]. Kidney Int Suppl, 2005, 97:S62-S67.
38	Yamada K, Kobayashi N, Ikeda T, et al. Down-regulation of core 1 beta1，3-galactosyltransferase and Cosmc by Th2 cytokine alters O-glycosylation of IgA1 [J]. Nephrol Dial Transplant, 2010, 25(12):3890-3897.
39	Maggi E, Biswas P, Del Prete G, et al. Accumulation of Th-2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis [J]. J Immunol, 1991, 146(4):1169-1174.
40	Maillard N, Wyatt RJ, Julian BA, et al. Current understanding of the role of complement in IgA nephropathy [J]. J Am Soc Nephrol, 2015, 26(7):1503-1512.
41	Magistroni R, D′Agati VD, Appel GB, et al. New developments in the genetics, pathogenesis, and therapy of IgA nephropathy [J]. Kidney Int, 2015, 88(5):974-989.
42	Serino G, Sallustio F, Curci C, et al. Role of let-7b in the regulation of N-acetylgalactosaminyltransferase 2 in IgA nephropathy [J]. Nephrol Dial Transplant, 2015, 30(7):1132-1139.
43	Reily C, Ueda H. Cellular signaling and production of galactose-deficient IgA1 in IgA nephropathy, an autoimmune disease [J]. J Immunol Res, 2014, 2014:197548.
44	Kiryluk K, Li Y. Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens [J]. Nat Genet, 2014, 46(11):1187-1196.
45	Hirano K, Amano H, Kawamura T, et al. Tonsillectomy reduces recurrence of IgA nephropathy in mesangial hypercellularity type categorized by the Oxford classification [J]. Clin Exp Nephrol, 2015, Epub ahead of print.
46	Komatsu H, Sato Y, Miyamoto T, et al. Significance of tonsillectomy combined with steroid pulse therapy for IgA nephropathy with mild proteinuria [J]. Clin Exp Nephrol, 2016, 20(1):94-102.
47	Coppo R. The intestine-renal connection in IgA nephropathy [J]. Nephrol Dial Transplant, 2015, 30(3):360-366.
48	Smerud HK, Barany P, Lindstrom K, et al. New treatment for IgA nephropathy: enteric budesonide targeted to the ileocecal region ameliorates proteinuria [J]. Nephrol Dial Transplant, 2011, 26(10):3237-3242.
49	Filiopoulos V, Vlassopoulos D. Steroids with local enteric action in IgA nephropathy and the association between kidney and bowel disease [J]. Nephrol Dial Transplant, 2012, 27(3):1265-1266.

[1]	Xiaoli Yi, Shasha Hu, Yan Zhang. Impact of HER-2 low expression on response of neoadjuvant chemotherapy and prognosis in breast cancer patients [J]. Chinese Journal of Breast Disease(Electronic Edition), 2023, 17(06): 340-346.
[2]	Jie Shi, Yuntao Li, Haiyan Gao. Prognosis of node-positive luminal A breast cancer patients with neoadjuvant and adjuvant chemotherapy and influencing factors [J]. Chinese Journal of Breast Disease(Electronic Edition), 2023, 17(06): 353-361.
[3]	Zeying Jiang, Anting Wang, Jiaoli Wang, Ci Chen, Qiuling Zhou, Yanjuan Huang, Fang Zhou, Yan Xue, Jianfeng Zhou, Wenyong Tan, Meifang Du. Effect of multiple plant oils combination in preventing the chemoradiotherapy induced toxicities [J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2023, 18(06): 523-527.
[4]	Wei Zhang. Dentoalveolar surgery: The pioneer of comfortable treatment [J]. Chinese Journal of Stomatological Research(Electronic Edition), 2023, 17(06): 386-388.
[5]	Dechen Wang, Kang Yang, Zijie Yang, Mingbin Gui, Lianping Qu, Xiaofeng Zhang, Feng Gao. Progress of microsatellite stability state and PD-1/PD-L1/IDO in colorectal carcinoma [J]. Chinese Archives of General Surgery(Electronic Edition), 2023, 17(06): 462-465.
[6]	Yanhui Zhang, Jiao Zhang, Zhixian Zhu. Effect of indwelling anal tube on anastomotic leakage after laparoscopic total mesangectomy after neoadjuvant chemoradiotherapy in patients with middle and low rectal cancer [J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 25-28.
[7]	Bo Kong, Jing Zhang, Ke Lyu. Review on the role of ultrasonography in the diagnosis and treatment of complex ventral hernia [J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2023, 17(06): 670-673.
[8]	Xiaoyong Wei. Discussion on the focus issues of conversion therapy for primary liver cancer [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 602-607.
[9]	Chenrui Wu, Rui Liao, Qiang He. Hepatic arterial infusion chemotherapy combined immunotargeted therapy for multiple metastatic hepatocellular carcinoma in a multi-disciplinary treatment model: a case report [J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2023, 12(06): 713-716.
[10]	Huiying Ma, Xinling Fan, Shirui Tan, Jiayun Chen, Ying Cao, Yuan Xu, Jing Jin, Yuan Tang. Magnetic resonance linac for locally advanced rectal cancer: a preliminary experience [J]. Chinese Journal of Colorectal Diseases(Electronic Edition), 2023, 12(06): 519-523.
[11]	Meng Wu, Guozhong Wu, Guihong Wang, Liangliang Duan, Jie Shi, Xu Wang, Ting Yu, Wei Liu. Correlation between neutrophil-lymphocyte ratio and renal tubular atrophy/interstitial fibrosis in patients with IgA nephropathy [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(9): 972-979.
[12]	Ruixue Yue, Lingxin Kong, Xin Hao, Jinqiang Yang, Meng Han, Guozhong Cui, Jianjun Wang, Zhisheng Zhang, Fanting Kong, Wei Zhang, Wenbo He, Xianqiao Li, Xinping Zhou, Donghong Xu, Chongzhu Hu. HER2 protein expression levels predict efficacy of neoadjuvant therapy in breast cancer: A real-world study [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(07): 765-770.
[13]	Meisha Fu, Yuhua Zhou, Hui Li, Chunyan Xue. Effect of lymphocyte immunotherapy on T lymphocyte subset distribution and PD1/PD-L1 expression in patients with recurrent miscarriage [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(06): 726-730.
[14]	Minjie Zhang, Xiaoshan Zhang, Shasha Duan, Yilu Shi, Jie Zhao, Tianhao Bai, Yaxi Wang. Hydrogen for treatment of myocardial ischemia-reperfusion injury: mechanism and prospect [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(06): 744-748.
[15]	Yingqian Li, Huashan Li. Evaluation of treatment methods for complete rectal prolapse: a real world study [J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(06): 700-705.

Please choose a citation manager

Content to export