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Chinese Journal of Kidney Disease Investigation(Electronic Edition) ›› 2017, Vol. 06 ›› Issue (01): 39-43. doi: 10.3877/cma.j.issn.2095-3216.2017.01.009

Special Issue:

• Review • Previous Articles     Next Articles

Dietary restriction in renal protection

Siyang Wang1, Guangyan Cai1,()   

  1. 1. Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing 100853, China
  • Received:2016-12-09 Online:2017-02-28 Published:2017-02-28
  • Contact: Guangyan Cai
  • About author:
    Corresponding author: Cai Guangyan, Email:

Abstract:

Dietary restriction, also called calorie restriction, is now widely studied as a new intervention. Its effect of prolonging life has been fully demonstrated. For example, it can significantly extend lifespan of the fly, worms, rodents, and mammalian models. Adjusting the intake of total calorie or some nutrients also has prophylactic or therapeutic effects on aging-related kidney disease and acute or chronic kidney injury. Calorie restriction mimetics has also been studied deeply. The mechanisms of the protection involve increased autophagy, reduced inflammation and oxidative stress, increased insulin sensitivity, and up-regulation of SIRT1, etc. It is important to carry out deep researches on the mechanism of calorie restriction so as to recommend more accurate intervention plans of diets or drugs.

Key words: Dietary restriction, Kidney injury, Aging

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