The role of the HIF-PHD axis in renal ischemia-reperfusion injury

doi:10.3877/cma.j.issn.2095-3216.2020.03.006

Abstract

Abstract:

Ischemia reperfusion is the main cause of rapid deterioration of renal function in acute kidney injury (AKI). It has been known that hypoxia-inducible factor (HIF) plays an important role in the process of AKI. This paper reviewed the conception, regulatory mechanism, and the role of the HIF-prolyl hydroxylase (PHD) axis in renal ischemia-reperfusion injury, so as to better understand the mechanism of AKI, helping to find new therapeutic targets and renal protection methods.

Key words: Hypoxia-inducible factor (HIF), Prolyl hydroxylase (PHD), AKI, Ischemia-reperfusion injury

Jingyao Yan, Fengmin Shao, Huanhuan Zhao, Qiuxia Han, Xiaonan Ding, Wenjia Geng, Hanyu Zhu. The role of the HIF-PHD axis in renal ischemia-reperfusion injury[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2020, 09(03): 120-123.

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