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Chinese Journal of Kidney Disease Investigation(Electronic Edition) ›› 2020, Vol. 09 ›› Issue (04): 181-185. doi: 10.3877/cma.j.issn.2095-3216.2020.04.007

Special Issue:

• Review • Previous Articles     Next Articles

Research progress of the role of B lymphocytes in lupus nephritis

Shang Wang1, Li Xiang2, Guoshuang Xu2,()   

  1. 1. The 14th Squadron of the Fourth Team, Air Force Military Medical University, Xi′an 710038
    2. Department of Nephrology, First Affiliated Hospital of Air Force Military Medical University, Xi′an 710032; Shaanxi Province, China
  • Received:2020-06-18 Online:2020-08-28 Published:2020-08-28
  • Contact: Guoshuang Xu
  • About author:
    Corresponding author: Xu Guoshuang, Email:

Abstract:

Lupus nephritis (LN) is a major disease that seriously threatens the health of Chinese people. B lymphocytes are involved not only in the pathological process of systemic damage, but also in the autoimmune pathogenesis of renal disease, and are the biggest driving force for the production of autoantibodies, the deposition of immune complexes in the kidney, and the activation of complement, which lead to kidney damage. In recent years, the treatment of LN targeting B lymphocytes and their activation pathways has shown promising prospects. This article briefly reviewed the research progress of B lymphocytes roles in LN.

Key words: Systemic lupus erythematosus, Lupus nephritis, B lymphocytes, B lymphocyte stimulator, A proliferation-inducing ligand (APRIL), B-cell activating factor (BAFF)/APRIL receptors

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