Mechanism of the development of acute lung injury after acute kidney injury

doi:10.3877/cma.j.issn.2095-3216.2020.05.004

Abstract

Abstract:

Acute kidney injury (AKI) is a common complication of critically ill patients, and the morbidity and mortality rate are increasing year by year. The prognosis of AKI patients is related to the damage of remote organs. The lung, heart, liver, and intestine are the most easily affected organs, with acute lung injury (ALI) being the most common. Concurrent ALI will lead to an increase in AKI mortality. The mechanisms of AKI-induced ALI include inflammation, increased levels of cytokines, oxidative stress, and apoptosis, etc. This article reviewed the mechanism of AKI-induced ALI for exploration of new therapeutic targets and improvement of the prognosis.

Key words: Acute kidney injury, Acute lung injury, Inflammation, Cytokine, Oxidative stress, Apoptosis

Pan Zhou, Xi Qiao. Mechanism of the development of acute lung injury after acute kidney injury[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2020, 09(05): 211-215.

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URL: https://zhsbyjdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-3216.2020.05.004

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