To explore the correlation between renal function damage and interleukin-23 (IL-23), uric acid (UA), monocyte chemoattractant protein-1 (MCP-1) in elderly patients with hyperuricemia (HUA).

A total of 112 elderly HUA patients in our hospital from March 2020 to October 2021 were selected. The clinical and laboratory indicators including IL-23 and MCP-1 were collected. Logistic multivariate regression model was used to analyze the correlation between serum indicators and occurrence of renal function damage in the patients. Spearman correlation coefficient model was used to analyze the relationship between levels of serum indicators and the degree of renal function damage. And receiver operating characteristic (ROC) curve was used to evaluate the value of serum indicators in predicting renal function damage in the patients.

Compared with patients with normal renal function, the patients with renal function damage showed longer courses of disease, higher proportions of complicated hypertension, higher levels of serum IL-23, UA, and MCP-1, but lower GFR (P<0.05). After adjustment, it was found that there is a correlation between the occurrence of renal function damage and the levels of serum IL-23, UA, and MCP-1 (P<0.05). The degree of the renal function damage was also positively correlated with the levels of serum IL-23, UA, and MCP-1 (P<0.05), and patients with severe renal function damage had the highest levels of serum IL-23, UA, and MCP-1 (P<0.05). The area under the curve (AUC) of the combined serum IL-23, UA, and MCP-1 for prediction of renal function damage was 0.892, which was greater than each of the indicator alone.

In the elderly patients with HUA, both the occurrence and severity of the renal function damage were positively correlated with the serum levels of IL-23, UA, and MCP-1. The combination of these three indicators may have more value for prediction of the renal function damage in the elderly patients with HUA.