To investigate the influencing factors of renal insufficiency in children with Henoch-Schönlein purpura nephritis.

The clinical data of 165 children with Henoch-Schönlein purpura nephritis treated in our hospital were retrospectively analyzed. Levels of serum IgG subclasses were collected. Cox regression model was used to analyze the influencing factors of renal insufficiency in the children with Henoch-Schönlein purpura nephritis.

The incidence of renal insufficiency was 35.15%. The levels of IgG1, IgG2, IgG3, and IgG4 in the patients with renal insufficiency were lower than those in the patients without renal insufficiency (P<0.05). IgG1 (RR=0.435, 95%CI: 0.249-0.671, P=0.013), IgG2 (RR=0.452, 95%CI: 0.302-0.668, P=0.010), IgG3 (RR=0.396, 95%CI: 0.245-0.676, P=0.012), and IgG4 (RR=0.471, 95%CI: 0.220-0.668, P=0.018) were the protective factors against renal insufficiency (P<0.05). Repeated rash (RR=4.189, 95%CI: 2.637-5.952, P=0.019), elevated platelet count (RR=4.157, 95%CI: 2.881-4.762, P<0.001), elevated blood pressure (RR=5.220, 95%CI: 2.314-6.888, P=0.001), elevated blood glucose (RR=5.125, 95%CI: 3.582-6.720, P<0.001), anemia (RR=5.231, 95%CI: 4.037-7.869, P=0.007), crescent formation (RR=5.172, 95%CI: 3.562-7.074, P=0.004), renal tubular atrophy (RR=5.519, 95%CI: 3.289-6.968, P=0.021), renal interstitial fibrosis (RR=6.460, 95%CI: 4.560-7.887, P=0.003), and non-compliance with treatment (RR=4.994, 95%CI: 3.462-6.840, P=0.001) were risk factors for the renal insufficiency (P<0.05).

IgG subclasses levels, repeated rash, elevated platelets, elevated blood pressure, elevated blood glucose, anemia, crescent formation, tubular atrophy, renal interstitial fibrosis, and non-compliance with treatment were the influencing factors of renal insufficiency in the children patients with Henoch-Schönlein purpura nephritis.