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Chinese Journal of Kidney Disease Investigation(Electronic Edition) ›› 2024, Vol. 13 ›› Issue (02): 79-86. doi: 10.3877/cma.j.issn.2095-3216.2024.02.004

• Original Article • Previous Articles    

Efficacy of mesenchymal stem cells-derived exosomes in the treatment of diabetic kidney disease in animals: a meta-analysis

Jingxuan Shi1, Yuanyuan Jiao2, Jingwei Tian3, Li Zhuo4,()   

  1. 1. China-Japan Friendship Institute of Clinical Medical Sciences, Beijing 100029; Department of Nephrology, China-Japan Friendship Hospital, Beijing 100029
    2. Department of Nephrology, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037
    3. Capital Medical University China-Japan Friendship School of Clinical Medicine, Beijing 100029; Department of Nephrology, Beijing Sixth Hospital, Beijing 100007; China
    4. Department of Nephrology, China-Japan Friendship Hospital, Beijing 100029
  • Received:2023-02-14 Online:2024-04-28 Published:2024-05-13
  • Contact: Li Zhuo

Abstract:

Objective

To systematacially evaluate the efficacy of exosomes derived from mesenchymal stem cells in the treatment of diabetic kidney disease of animals.

Methods

Relevant articles in the Embase and PubMed databases were retrieved on mesenchymal stem cells-derived exosomes in the treatment of diabetic kidney disease of mice. The retrieval time was from the establishment of the databases until November 25, 2022. SYRCLE′s risk of bias tool was used to evaluate the risk of bias of the animal studies. Meta-analysis was performed by means of the RevMan5.4 software from the Cochrane Collaboration network.

Results

A total of 4 randomized controlled animal experiments were included. There were altogether no less than 98 mice, with no less than 33 mice in the exosome treatment group, 32 mice in the blank control group, and no less than 33 mice in the animal model control group. The results of meta-analysis showed that the blood urea nitrogen level (SMD=-1.97, 95%CI: -3.56 to -0.39, P=0.01) and blood glucose level (SMD=-1.98, 95%CI: -17.45 to -2.22, P=0.002) decreased significantly, while the changes of body weight (SMD=-1.47, 95%CI: -0.21 to 3.16, P=0.09), urinary creatinine (SMD=-1.34, 95%CI: -7.51 to 4.83, P=0.67), and 24 h urinary albumin (SMD=-3.29, 95%CI: -8.40 to -1.82, P=0.21) were of no significant difference after the treatment with exosomes derived from mesenchymal stem cells in the mice diabetic nephropathy animals.

Conclusions

Exosomes derived from mesenchymal stem cells had certain efficacy in the treatment of diabetic kidney disease of animals, which still need to be further studied and verified.

Key words: Mesenchymal stem cells, Exosomes, Animal experiments, Diabetic kidney disease, Meta-analysis, Systematic evaluation

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