Research progress on the pathogenesis and intervention targets of contrast-induced acute kidney injury

doi:10.3877/cma.j.issn.2095-3216.2024.05.007

Abstract

Abstract:

With the increasing use of contrast media in clinical diagnosis and treatment，contrastinduced acute kidney injury （CIAKI） has become one of the main causes of renal insufficiency. CIAKI is characterized by a sudden decline in kidney function following contrast agent administration. The underlying pathophysiological mechanisms include renal medullary ischemia，direct contrast agent toxicity，oxidative stress，and inflammation. So far，except for the strategy of reducing the toxicity of contrast media，there is no effective means to prevent and treat CIAKI. This article reviewed the molecular mechanism of CIAKI，and introduced the potential value of targets related to apoptosis，inflammation，oxidative stress，and renal hemodynamic for the prevention and treatment of CIAKI，in order to provide reference for reducing the incidence of CIAKI，and improving the prognosis of the patients.

Key words: Contrast-induced acute kidney injury, Inflammation, Oxidative stress, Apoptosis

Xia Du, Mengqing Ma, Changchun Cao. Research progress on the pathogenesis and intervention targets of contrast-induced acute kidney injury[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2024, 13(05): 279-282.

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URL: https://zhsbyjdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-3216.2024.05.007

https://zhsbyjdzzz.cma-cmc.com.cn/EN/Y2024/V13/I05/279

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