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Chinese Journal of Kidney Disease Investigation(Electronic Edition) ›› 2025, Vol. 14 ›› Issue (03): 164-170. doi: 10.3877/cma.j.issn.2095-3216.2025.03.008

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Research progress on the role of gut-derived uremic toxins in the pathogenesis of cognitive impairment in patients with chronic kidney disease

Shitong Liu1, Nan Wang2,()   

  1. 1. Graduate School of Dalian Medical University,Dalian 116000
    2. Department of Nephrology,First Hospital Affiliated to Dalian Medical University,Dalian 116011; Liaoning Province,China
  • Received:2024-12-24 Online:2025-06-28 Published:2025-07-09
  • Contact: Nan Wang

Abstract:

Patients with chronic kidney disease (CKD) have a high prevalence of cognitive impairment, which is often overlooked and severely impacts their quality of life and survival time.Uremic toxins play an important role in the occurrence and development of cognitive impairment in CKD patients.Gut microbiota dysbiosis and the gut-derived uremic toxins (GUTs) produced due to their catabolism accelerate the progression of cognitive impairment in the patients.This article focused on discussing the potential role of key GUTs in the pathogenesis of cognitive impairment in CKD patients, and elaborated on relevant prevention and treatment measures, providing a reference for the clinical diagnosis and treatment of cognitive impairment in CKD patients.

Key words: Chronic kidney disease, Gut-derived uremic toxins, Intestinal flora, Cognitive impairment

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