Update on signaling pathways of podocyte injury

doi:10.3877/cma.j.issn.2095-3216.2013.06.006

Abstract

Abstract:

Podocytes are terminally differentiated cells located on the outer surface of the glomerular basement membrane with specific architecture and function, and play a key role in maintaining the structure and function of the glomerular filtration barrier. Accumulating evidence suggests that podocytes play a pivotal role in the pathogenesis and progression of glomerular disease and will become an efficient target for the novel therapy of chronic kidney disease. Many studies are now focused on the mechanisms of podocyte injury, the signaling pathways of which provide crucial clues to the pathogenetic mechanism. Interventions on the key factors in the signaling pathways will be potential therapies for podocytopathy. In this review, we highlight both the classic and latest signaling pathways within podocyte injury including Wnt/β-catenin, Notch signaling pathway, podocyte cytoskeleton regulatory signaling pathway, transforming growth factor-β (TGFβ)/ bone morphogenetic protein 7 (BMP-7) signaling pathway, and autophagy pathway.

Key words: Podocyte injury, Signaling pathways

Wei SHI, Xiao-fan TAN, Xing-chen ZHAO, Yuan-han CHEN. Update on signaling pathways of podocyte injury[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2013, 02(06): 304-309.

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https://zhsbyjdzzz.cma-cmc.com.cn/EN/Y2013/V02/I06/304

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