Role and mechanism of autophagy in progression of diabetic nephropathy

doi:10.3877/cma.j.issn.2095-3216.2016.04.007

Abstract

Abstract:

Diabetic nephropathy is one of the main causes for end-stage renal disease, whose pathogenesis is unclear yet. Autophagy is a highly conserved cytology event which can degrade intracellular abnormal proteins and organelles, maintaining the intracellular homeostasis and playing a critical role in many acute and chronic kidney diseases. It was demonstrated that impairment of autophagy is implicated in the pathogenesis of diabetic nephropathy. Focusing on different types of cells in the kidneys, this article reviewed related progress of research on the role of autophagy in diabetic nephropathy.

Key words: Autophagy, Diabetic nephropathy

Kehong Chen, Yani He. Role and mechanism of autophagy in progression of diabetic nephropathy[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2016, 05(04): 172-176.

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