Current epidemiology of nephrotic syndrome

doi:10.3877/cma.j.issn.2095-3216.2017.04.002

Abstract

Abstract:

Nephrotic syndrome is common in patients with chronic kidney diseases. With the improvement of the socioeconomic status, lifestyle, and living environment, the epidemiological characteristics of nephrotic syndrome have changed significantly. The incidence of nephrotic syndrome is increasing in the elderly, pregnant women, and patients with diabetes and cancer. The major complications of acute kidney injury, thromboembolic events, and infections, have shown novel features in the nephrotic patients. Therefore, it is of great significance to understand the epidemiological characteristics of nephrotic syndrome for the clinical precise diagnosis and treatment of nephrotic syndrome, as well as improvement of its clinical control.

Key words: Nephrotic syndrome, Epidemiology

Yani He, Weiwei Zhang. Current epidemiology of nephrotic syndrome[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2017, 06(04): 149-153.

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References 33

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数据库	时间(年)	肾活检病例数	平均年龄(岁)	肾病综合征比例(%)
西班牙	1994～2001	9 378	－	35.5
意大利	1987～1993	13 835	－	27.1
捷克共和国	1994～2011	10 472	44.5	39.3
日本	2007～2010	7 034	47.9±20.9	24.2
巴西	1993～2007	9 062	35.1±18.7	39.0
乌拉圭	1980～2003	2 054	39.1±19.6	30.0
法国	1976～2002	1 742	41	23.2
芬兰	1980～2000	3 310	44	16.4
罗马尼亚	1995～2004	635	38.5±15.2	52.0
塞尔维亚	1987～2006	1 626	39.1±13.8	53.6
南非	2000～2009	1 284	36.8±14.0	52.5
印度	1986～2002	5 415	－	65.0
伊朗	1998～2001	407	33.6±15.7	70.0
香港	1993～1997	1 629	38.7	23.3

数据库	时间(年)	肾活检病例数	平均年龄(岁)	肾病综合征比例(%)
西班牙	1994～2001	9 378	－	35.5
意大利	1987～1993	13 835	－	27.1
捷克共和国	1994～2011	10 472	44.5	39.3
日本	2007～2010	7 034	47.9±20.9	24.2
巴西	1993～2007	9 062	35.1±18.7	39.0
乌拉圭	1980～2003	2 054	39.1±19.6	30.0
法国	1976～2002	1 742	41	23.2
芬兰	1980～2000	3 310	44	16.4
罗马尼亚	1995～2004	635	38.5±15.2	52.0
塞尔维亚	1987～2006	1 626	39.1±13.8	53.6
南非	2000～2009	1 284	36.8±14.0	52.5
印度	1986～2002	5 415	－	65.0
伊朗	1998～2001	407	33.6±15.7	70.0
香港	1993～1997	1 629	38.7	23.3

项目		2007年	2008年	2009年	2010年
总例数		818	1 582	3 336	7 442
肾病综合征(%)		16.90	16.40	21.30	25.40
肾病综合征病因(前5位，%)		?	?	?	?
?	原发肾小球疾病(除外IgA肾病)	65	69.10	62.30	66.70
?	糖尿病肾病	10.90	5.80	12	7.50
?	肾淀粉样变	6.50	5.00	3.80	3.90
?	IgA肾病	5.80	3.50	4.20	3.50
?	狼疮肾炎	2.90	3.10	4.20	5.60
原发性肾病综合征病理类型(前3位，%)		?	?	?	?
?	微小病变	31.90	44.10	38.90	50
?	膜性肾病	44	31.30	40.30	32.60
?	局灶节段肾小球硬化	11	14	10.60	11.80
常见病理类型表现为肾病综合征的比例(%)		?	?	?	?
?	膜性肾病	59.5	51.6	68.7	68.8
?	微小病变	55.8	57.3	79.6	85.3
?	局灶节段肾小球硬化	31.3	40.0	41.6	55.0
?	IgA肾病	3.3	2.1	3.0	3.1

项目		2007年	2008年	2009年	2010年
总例数		818	1 582	3 336	7 442
肾病综合征(%)		16.90	16.40	21.30	25.40
肾病综合征病因(前5位，%)		?	?	?	?
?	原发肾小球疾病(除外IgA肾病)	65	69.10	62.30	66.70
?	糖尿病肾病	10.90	5.80	12	7.50
?	肾淀粉样变	6.50	5.00	3.80	3.90
?	IgA肾病	5.80	3.50	4.20	3.50
?	狼疮肾炎	2.90	3.10	4.20	5.60
原发性肾病综合征病理类型(前3位，%)		?	?	?	?
?	微小病变	31.90	44.10	38.90	50
?	膜性肾病	44	31.30	40.30	32.60
?	局灶节段肾小球硬化	11	14	10.60	11.80
常见病理类型表现为肾病综合征的比例(%)		?	?	?	?
?	膜性肾病	59.5	51.6	68.7	68.8
?	微小病变	55.8	57.3	79.6	85.3
?	局灶节段肾小球硬化	31.3	40.0	41.6	55.0
?	IgA肾病	3.3	2.1	3.0	3.1

中心	时间(年)	例数	肾病综合征病理类型分布(%)
中心	时间(年)	例数	IMN	MCD	IgAN	FSGS	LN	DN	HBV-GD
北京	1993～2007	1 532	20.7	20.4	10.5	4.3	16.0	11.0	10.5
武汉	1994～2014	1 004	36.9	19.6	26.7	9.9	14.6	1.0	4.2

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