Effect of endoplasmic reticulum stress and drug intervention on podocyte injury in diabetic nephropathy

doi:10.3877/cma.j.issn.2095-3216.2021.02.007

Abstract

Abstract:

Podocyte injury or shedding will cause the glomerular basement membrane to be exposed and increase its permeability, which is an important reason for the continuous progression of diabetic nephropathy (DN). Endoplasmic reticulum stress (ERS) is an adaptive response of cells. Moderate ERS has a protective effect on cells, and when the intensity of external stimuli exceeds the self-protective balance of the endoplasmic reticulum, ERS will activate various apoptosis signaling pathways to remove damaged cells to protect the milieu interne stability. In the state of diabetes, the ERS signaling pathway can promote the injury and apoptosis of podocyte. Therefore, the ERS signaling pathway and its key factors have become the key targets for the prevention and treatment of DN. This article reviewed the progress of research on the effect of ERS in podocyte damage of diabetic nephropathy and on the drug intervention.

Key words: Diabetic nephropathy, Podocyte, Endoplasmic reticulum stress, Signaling pathway

Zhaoan Guo, Lina Sun. Effect of endoplasmic reticulum stress and drug intervention on podocyte injury in diabetic nephropathy[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2021, 10(02): 96-99.

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