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Chinese Journal of Kidney Disease Investigation(Electronic Edition) ›› 2025, Vol. 14 ›› Issue (02): 104-109. doi: 10.3877/cma.j.issn.2095-3216.2025.02.007

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Research progress on treating diabetic kidney disease by regulating endoplasmic reticulum stress signaling pathway

Rongrong Zhu1, Jianqin Wang2,()   

  1. 1. Lanzhou Univesity, Lanzhou 730000
    2. Second Hospital of Lanzhou University, Lanzhou 730030; Gansu Province, China
  • Received:2024-11-26 Online:2025-04-28 Published:2025-05-12
  • Contact: Jianqin Wang

Abstract:

Diabetic nephropathy (DKD), as a characteristic microvascular complication of diabetes, has become the leading cause of chronic kidney disease. However, there is still a lack of effective means to prevent its progression to end-stage renal disease (ESRD). Recent studies have suggested that endoplasmic reticulum stress (ERS) was involved in the occurrence and progression of DKD, and the ERS signaling pathway may become a new target for the treatment of DKD. This article reviewed the research progress on treating DKD by regulating the endoplasmic reticulum stress signaling pathway.

Key words: Diabetic kidney disease, Endoplasmic reticulum stress, Treatment, Signaling pathway

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