Abstract:
Objective To evaluate the efficacy and safety of coated aldehyde oxystarch in the treatment of chronic renal failure.
Methods Retrievals were made in the databases of CNKI, Wanfang, VIP, PubMed, EMbase, and Cochrane Library, etc. Randomized controlled trials on the treatment of chronic renal failure with aldehyde oxidized starch were screened out. And meta-analysis was performed with the RevMan 5.4 software.
Results Seven randomized controlled trials involving 838 patients with chronic renal failure were included. The meta-analysis results showed that the experimental group was significantly superior to the control group in terms of clinical efficacy in treating chronic renal failure (OR=9.19, 95%CI: 4.54-18.62, P<0.01), reducing blood urea nitrogen (MD=-5.21, 95%CI: -6.05- -4.35, P<0.01), decreasing serum creatinine (MD=-69.60, 95%CI: -98.18 - -41.03, P<0.01), and improving creatinine clearance rate (MD=5.26, 95%CI: 2.34-8.18, P<0.01). No serious adverse events were reported.
Conclusion Coated aldehyde oxystarch had a positive role in reducing blood urea nitrogen and serum creatinine, as well as improving creatinine clearance rate in the patients with chronic renal failure.
Key words:
Coated aldehyde oxystarch,
Chronic renal failure,
Meta-analysis
Hongli Chen, Feihong Ren, Pengyuan Liang, Yuyang Wang, Yongli Zhan. Meta-analysis of the efficacy and safety of coated aldehyde oxystarch in the treatment of chronic renal failure[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2025, 14(06): 309-316.