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中华肾病研究电子杂志 ›› 2014, Vol. 03 ›› Issue (05) : 251 -254. doi: 10.3877/cma.j.issn.2095-3216.2014.05.006

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钙离子拮抗剂类降压药在肾脏病中的合理应用
王伟铭1,(), 徐丽梨1   
  1. 1.200025 上海交通大学医学院附属瑞金医院肾脏科
  • 出版日期:2014-10-15
  • 通信作者: 王伟铭
  • 基金资助:
    国家十二五科技攻关项目(2011BAI10B06)上海市重中之重学科建设项目卫生行业科研专项(201002010)

Rational application of antihypertensive calcium channel blockers in renal diseases

Weiming Wang1,(), Lili Xu1   

  1. 1.Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine,Shanghai 200025, China
  • Published:2014-10-15
  • Corresponding author: Weiming Wang
引用本文:

王伟铭, 徐丽梨. 钙离子拮抗剂类降压药在肾脏病中的合理应用[J/OL]. 中华肾病研究电子杂志, 2014, 03(05): 251-254.

Weiming Wang, Lili Xu. Rational application of antihypertensive calcium channel blockers in renal diseases[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2014, 03(05): 251-254.

中国人群高血压发病率较高,其中继发性高血压第一位的病因就是慢性肾脏病(CKD)。 对于CKD 高血压患者首选血管紧张素转换酶抑制剂(ACEI)或血管紧张素II 受体拮抗剂(ARB)类药物,而单药治疗往往血压控制不佳,需联合其它降压药物治疗。 钙离子拮抗剂(CCB)是一线降压药物,既往考虑其对肾脏副作用而较少应用于CKD 患者。 随着研究进展及新型制剂的研发,CCB 类药物在CKD 高血压治疗中亦有一定地位及优势,合理的应用可改善肾脏病预后,给患者带来益处。

The incidence of hypertension is high in the Chinese population. And the first cause of secondary hypertension is chronic kidney disease (CKD). To control the hypertension in CKD patients,angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) is the first choice.However, as single drug use of ACEI or ARB does not have satisfactory effect in controlling the hypertension of CKD patients, combination of other antihypertensive drugs is usually needed. Calcium channel blockers(CCB) are first-line antihypertensive drugs, but were less used in CKD patients previously due to their adverse effects. With the research progress and the development of new preparations, CCB have their certain places and advantages in treatment of hypertension patients with CKD. Rational application of CCB can improve prognosis of the kidney so as to benefit the patients.

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