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中华肾病研究电子杂志 ›› 2015, Vol. 04 ›› Issue (03) : 123 -126. doi: 10.3877/cma.j.issn.2095-3216.2015.03.003

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高通量透析的研究进展
那宇1,(), 柳慧敏1   
  1. 1. 100101 北京,解放军第三○六医院肾内科
  • 出版日期:2015-06-28
  • 通信作者: 那宇
  • 基金资助:
    "十二五"国家科技支撑计划项目(2011BAI10B08)

Progress of research on high flux hemodialysis

Yu Na1,(), Huimin Liu1   

  1. 1. Department of Nephrology, 306 Hospital of PLA, Beijing 100101, China
  • Published:2015-06-28
  • Corresponding author: Yu Na
  • About author:
    Corresponding author: Na Yu, Email:
引用本文:

那宇, 柳慧敏. 高通量透析的研究进展[J]. 中华肾病研究电子杂志, 2015, 04(03): 123-126.

Yu Na, Huimin Liu. Progress of research on high flux hemodialysis[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2015, 04(03): 123-126.

血液透析是终末期肾病患者最有效的维持生命的治疗方法,透析效果的好坏取决于透析方式的选择。高通量血液透析(HFHD)以其大孔径人工合成膜的高通透特性明显优于低通量透析的透析效果,其高毒素清除率及高超滤作用使其成为目前最合理的透析方式。临床上常通过应用高通量血液透析来调节慢性肾衰竭患者钙磷代谢平衡、增加β2-微球蛋白(β2-MG)清除、改善血脂代谢紊乱及改善营养状况等。但高通量血液透析在应用过程中亦存在一些问题,如细菌等微生物可能通过透析膜进入血液,对透析用水和透析液的质量控制要求较高等。提高跨膜压使血液侧压力高于透析液侧压力及使用超纯透析液是保证高通量透析治疗顺利进行的关键。

Hemodialysis is the most effective life-sustaining treatment for patients with end-stage renal disease; its effects depend on the choice of dialysis modes. High flux hemodialysis (HFHD) is better than low flux dialysis due to its high permeability of large aperture synthetic membrane, and has currently become the most rational way of dialysis for its high clearance rate of toxins and excellent filtering effect. Clinically HFHD is utilized for adjusting calcium and phosphorus metabolism balance of patients with chronic renal failure, increasing the clearance rate of β2 microglobulin, and improving blood lipid metabolism disorders and nutrition status, etc. But there are still several problems in the process of the HFHD application, such as blood bacterial infection through the dialysis membrane, and the quality control of the dialysis water and dialysate, etc. Increasing the transmembrane pressure to make blood side pressure higher than lateral dialysis fluid pressure, and use of ultrapure dialysate are the keys to ensure smooth process of HFHD treatment.

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