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中华肾病研究电子杂志 ›› 2016, Vol. 05 ›› Issue (04) : 145 -151. doi: 10.3877/cma.j.issn.2095-3216.2016.04.001

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加强对正常蛋白尿糖尿病肾脏疾病的认识
孙林1,(), 陈超1   
  1. 1. 410011 中南大学湘雅二医院肾脏病研究所、湘雅二医院肾内科
  • 收稿日期:2016-05-21 出版日期:2016-08-28
  • 通信作者: 孙林
  • 基金资助:
    国家自然科学基金(81270812,81470960)

Strengthening the understanding of normoalbuminuric diabetic kidney disease

Lin Sun1,(), Chao Chen1   

  1. 1. Department of Nephrology, Institute of Kidney Disease, Second Xiangya Hospital Affiliated to Central South University, Changsha, Hunan 410011, China
  • Received:2016-05-21 Published:2016-08-28
  • Corresponding author: Lin Sun
  • About author:
    Corresponding author: Sun Lin, Email:
引用本文:

孙林, 陈超. 加强对正常蛋白尿糖尿病肾脏疾病的认识[J/OL]. 中华肾病研究电子杂志, 2016, 05(04): 145-151.

Lin Sun, Chao Chen. Strengthening the understanding of normoalbuminuric diabetic kidney disease[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2016, 05(04): 145-151.

糖尿病肾脏疾病(DKD)是导致终末期肾脏病(ESRD)的主要原因,早期及时诊断对防治DKD进展非常重要。以往DKD临床诊断多注重尿白蛋白排泄率(UAER),并以此作为诊断与临床分期的重要依据。实际上许多糖尿病(DM)有时表现为无临床诊断价值的蛋白尿,而以肾功能减退为突出肾脏受累表现,即正常蛋白尿糖尿病肾脏疾病(NADKD),或称无蛋白尿糖尿病肾病(nonalbuminuric diabetic nephropathy),及糖尿病无蛋白尿肾功能不全(nonalbuminuric renal impairment in diabetes)。本文结合国内外研究现状,从流行病学、病理、临床特征、诊断及治疗等方面对NADKD进行了描述,以翼引起同行重视。

Diabetic kidney disease (DKD) is a primary cause for end-stage renal disease (ESRD). Early diagnosis is very important for preventing the progression of DKD. Assessment of urinary albumin excretion rate (UAER) played a key role in the diagnosis and clinical stages of patients with DKD. Actually, many diabetic mellitus (DM) patients sometimes showed nonalbuminuric renal insufficiency, which was named normoalbuminuric diabetic kidney disease (NADKD), nonalbuminuric diabetic nephropathy, or nonalbuminuric renal impairment in diabetes. In this article, the authors discussed NADKD in epidemiology, pathology, clinical features, diagnosis and treatment, etc, hoping to attract attention from colleagues in nephrology.

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