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中华肾病研究电子杂志 ›› 2016, Vol. 05 ›› Issue (06) : 277 -280. doi: 10.3877/cma.j.issn.2095-3216.2016.06.009

所属专题: 文献

综述

连体动物模型的应用
刘东1, 孙雪峰2, 陈香美2,()   
  1. 1. 100853 北京,解放军总医院肾脏病科、解放军肾脏病研究所、肾脏疾病国家重点实验室、国家慢性肾病临床医学研究中心;100142 北京,空军总医院肾脏病科
    2. 100853 北京,解放军总医院肾脏病科、解放军肾脏病研究所、肾脏疾病国家重点实验室、国家慢性肾病临床医学研究中心
  • 收稿日期:2016-11-19 出版日期:2016-12-28
  • 通信作者: 陈香美
  • 基金资助:
    国家重大基础研究项目资助课题(2013CB530800); 国家自然科学基金资助课题(81270819)

Application of parabiosis animal model in biomedical research

Dong Liu1, Xuefeng Sun2, Xiangmei Chen2,()   

  1. 1. Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing 100853, China; Department of Nephrology, Air Force General Hospital, Chinese PLA, 30 Fu Cheng Road, Beijing 100142, China
    2. Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing 100853, China
  • Received:2016-11-19 Published:2016-12-28
  • Corresponding author: Xiangmei Chen
  • About author:
    Corresponding author: Chen Xiangmei, Email:
引用本文:

刘东, 孙雪峰, 陈香美. 连体动物模型的应用[J/OL]. 中华肾病研究电子杂志, 2016, 05(06): 277-280.

Dong Liu, Xuefeng Sun, Xiangmei Chen. Application of parabiosis animal model in biomedical research[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2016, 05(06): 277-280.

连体动物模型是通过外科手术的方式将两只动物连接起来,在伤口处发生血管再通而形成共享的循环系统,最终实现细胞和可溶性因子的交换。是一个研究循环因素影响组织器官功能的动物模型。利用异龄连体动物模型,可以观察到青年内环境影响老年小鼠的衰老表型,恢复某些衰老器官的功能;利用同龄连体模型,可以观察到相对健康的内环境对病理生理状态产生的影响。

The experimental model of parabiosis, which is set up through joining two animals by surgical operation, develops a common and shared circulatory system. The blood cells and soluble factors can exchange continuously at physiological levels through their intercommunicated blood circulation. The parabiosis animal model is considered as a powerful model to observe the effect of circulating factors on organisms function. In the heterochronic parabiosis model, old mice exposed to a youthful systemic milieu exhibited rejuvenated organism function. And in the isochronic parabiosis model, it was observed that relative healthy systemic milieu affected the pathophysiological process of its attached partner.

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