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中华肾病研究电子杂志 ›› 2021, Vol. 10 ›› Issue (02) : 96 -99. doi: 10.3877/cma.j.issn.2095-3216.2021.02.007

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综述

内质网应激及药物干预对糖尿病肾病足细胞损伤的作用
郭兆安1,(), 孙丽娜2   
  1. 1. 250011 济南,山东中医药大学附属医院肾内科、山东省中医院
    2. 276000 临沂市人民医院肾内科
  • 收稿日期:2020-07-29 出版日期:2021-04-30
  • 通信作者: 郭兆安
  • 基金资助:
    国家自然科学基金面上项目(81874440); 山东省中医药科技发展计划项目(2017-467)

Effect of endoplasmic reticulum stress and drug intervention on podocyte injury in diabetic nephropathy

Zhaoan Guo1,(), Lina Sun2   

  1. 1. Department of Nephrology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Provincial Hospital of Traditional Chinese Medicine, Ji′nan 250011
    2. Department of Nephrology, Linyi City People′s Hospital, Linyi 276000; Shandong Province, China
  • Received:2020-07-29 Published:2021-04-30
  • Corresponding author: Zhaoan Guo
引用本文:

郭兆安, 孙丽娜. 内质网应激及药物干预对糖尿病肾病足细胞损伤的作用[J/OL]. 中华肾病研究电子杂志, 2021, 10(02): 96-99.

Zhaoan Guo, Lina Sun. Effect of endoplasmic reticulum stress and drug intervention on podocyte injury in diabetic nephropathy[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2021, 10(02): 96-99.

足细胞损伤或脱落会导致肾小球基底膜裸露且通透性增加,是糖尿病肾病(DN)持续进展的重要原因。内质网应激(ERS)是细胞的一种适应性反应。适度的ERS对细胞具有保护作用,而外界刺激强度超过内质网的自身保护平衡时,ERS会激活各种凋亡信号通路以清除受损细胞来保护内环境的稳定。糖尿病状态下,ERS信号通路会促进足细胞损伤和凋亡。因此,ERS信号通路及其关键因子,已成为防治DN的关键靶点。本文综述了ERS对糖尿病肾病足细胞损伤的影响及药物干预作用研究进展。

Podocyte injury or shedding will cause the glomerular basement membrane to be exposed and increase its permeability, which is an important reason for the continuous progression of diabetic nephropathy (DN). Endoplasmic reticulum stress (ERS) is an adaptive response of cells. Moderate ERS has a protective effect on cells, and when the intensity of external stimuli exceeds the self-protective balance of the endoplasmic reticulum, ERS will activate various apoptosis signaling pathways to remove damaged cells to protect the milieu interne stability. In the state of diabetes, the ERS signaling pathway can promote the injury and apoptosis of podocyte. Therefore, the ERS signaling pathway and its key factors have become the key targets for the prevention and treatment of DN. This article reviewed the progress of research on the effect of ERS in podocyte damage of diabetic nephropathy and on the drug intervention.

图1 ERS不同信号通路对糖尿病肾病足细胞的影响
[1]
Gnudi L, Coward R, Long D. Diabetic nephropathy: perspective on novel molecular mechanisms [J]. Trends Endocrinol Metab, 2016, 27(11): 820-830.
[2]
中华医学会糖尿病学分会微血管并发症学组. 中国糖尿病肾脏疾病防治临床指南[J]. 中华糖尿病杂志,2019, 11(1): 15-28.
[3]
周梦文,杨杨,卢从群,等. 维生素D受体在糖尿病肾病足细胞损伤[J]. 中华肾脏病杂志,2020, 36(5): 385-393.
[4]
张利平,孟燕,元小冬,等. 内质网应激及介导细胞凋亡信号转导研究进展[J].生物医学工程与临床,2018, 22(2): 214-220.
[5]
Fan Y, Lee K, Wang N, et al. The role of endoplasmic reticulum stress in diabetic nephropathy [J]. Curr Diab Rep, 2017, 17(3): 17.
[6]
Cao Y, Hao Y, Li H, et al. Role of endoplasmic reticulum stress in apoptosis of differentiated mouse podocytes induced by high glucose [J]. Int J Mol Med, 2014, 33(4): 809-816.
[7]
Sever S, Altintas MM, Nankoe SR, et al. Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease [J]. J Clin Invest, 2007, 117(8): 2095-2104.
[8]
Dai H, Liu Q, Liu B. Research progress on mechanism of podocyte depletion in diabetic nephropathy [J]. J Diabetes Res, 2017, 2017: 2615286.
[9]
Sanchez-Lopez E, Zimmerman T, Gomez del Pulgar T, et al. Choline kinase inhibition induces exacerbated endoplasmic reticulum stress and triggers apoptosis via CHOP in cancer cells [J]. Cell Death Dis, 2013, 4(11): e933.
[10]
Cybulsky AV. The intersecting roles of endoplasmic reticulum stress, ubiquitin-proteasome system, and autophagy in the pathogenesis of proteinuric kidney disease [J]. Kidney Int, 2013, 84(1): 25-33.
[11]
Lee ES, Kim HM, Kang JS, et al. Oleanolic acid and N-acetylcysteine ameliorate diabetic nephropathy through reduction of oxidative stress and endoplasmic reticulum stress in a type 2 diabetic rat model [J]. Nephrol Dial Transplant, 2016, 31(3): 391-400.
[12]
Cybulsky AV. Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases [J]. Nat Rev Nephrol, 2017, 13(11): 681-696.
[13]
Yuan Y, Xu X, Zhao C, et al. The roles of oxidative stress, endoplasmic reticulum stress, and autophagy in aldosterone/mineralocorticoid receptor-induced podocyte injury [J]. Lab Invest, 2015, 95(12): 1374-1386.
[14]
Hassan H, Tian X, Inoue K, et al. Essential role of X-box binding protein-1 during endoplasmic reticulum stress in podocytes [J]. J Am Soc Nephrol, 2016, 27(4): 1055-1065.
[15]
Elimam H, Papillon J, Kaufman DR, et al. Genetic ablation of calcium-independent phospholipase A2γ induces glomerular injury in mice [J]. J Biol Chem, 2016, 291(28): 14468-14482.
[16]
Almanza A, Carlesso A, Chintha C, et al. Endoplasmic reticulum stress signalling- from basic mechanisms to clinical applications [J]. FEBS J, 2019, 286(2): 241-278.
[17]
徐倩,许银丰,杨杰杰,等. 内质网应激与细胞自噬的关系[J]. 中国细胞生物学学报,2020, 42(8): 1489-1500.
[18]
曹延萍,刘杰,潘风军,等. 内质网应激在糖尿病及糖尿病肾病中的研究进展[J]. 四川解剖学杂志,2012, 20(3): 15-20.
[19]
沈倩,赵鼎,王利,等. 黄芪汤对高糖诱导足细胞损伤的保护作用及机制研究[J]. 现代中西医结合杂志,2020, 29(5): 457-462.
[20]
Cao Y, Hao Y, Li H, et al. Role of endoplasmic reticulum stress in apoptosis of differentiated mouse podocytes induced by high glucose [J]. Int J Mol Med, 2014, 33(4): 809-816.
[21]
李艳,秦洁,张姬欣,等. 高糖、高同型半胱氨酸致足细胞内质网应激时白藜芦醇对CHOP通路的影响[J/CD]. 中华临床医师杂志(电子版), 2014, 8(3): 114-117.
[22]
Yamamoto S, Kuramoto K, Wang N, et al. Autophagy differentially regulates insulin production and insulin sensitivity [J]. Cell Rep, 2018, 23(11): 3286-3299.
[23]
Zhang MZ, Wang Y, Paueksakon P, et al. Epidermal growth factor receptor inhibition slows progression of diabetic nephropathy in association with a decrease in endoplasmic reticulum stress and an increase in autophagy [J]. Diabetes, 2014, 63(6): 2063-2072.
[24]
Kawakami T, Inagi R, Takano H, et al. Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells [J]. Nephrol Dial Transplant, 2009, 24(9): 2665-2672.
[25]
Hartleben B, Gödel M, Meyer-Schwesinger C, et al. Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice [J]. J Clin Invest, 2010, 120(4): 1084-1096.
[26]
张姬欣,柳洁,秦洁,等. JNK通路在AngⅡ所致肾小球足细胞内质网应激性凋亡中的作用[J]. 国际检验医学杂志,2013, 34(17): 2218-2220.
[27]
明建华,叶金云,张易祥,等.姜黄素对草鱼生长性能、抗氧化应激能力及核因子E2相关因子2 /抗氧化反应元件信号通路相关基因表达的影响[J].动物营养学报,2019, 31(2): 809-823.
[28]
邓文荣,石文清,李海俏,等. 姜黄素对糖尿病肾病大鼠肾功能及肾组织JNK、Notch2 / Hes1信号通路的影响 [J]. 山东医药,2020, 60(14): 5-8.
[29]
Gowd V, Kang Q, Wang Q, et al. Resveratrol: evidence for its nephroprotective effect in diabetic nephropathy [J]. Adv Nutr, 2020, 11(6): 1555-1568.
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