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中华肾病研究电子杂志 ›› 2021, Vol. 10 ›› Issue (02) : 96 -99. doi: 10.3877/cma.j.issn.2095-3216.2021.02.007

所属专题: 文献

综述

内质网应激及药物干预对糖尿病肾病足细胞损伤的作用
郭兆安1,(), 孙丽娜2   
  1. 1. 250011 济南,山东中医药大学附属医院肾内科、山东省中医院
    2. 276000 临沂市人民医院肾内科
  • 收稿日期:2020-07-29 出版日期:2021-04-30
  • 通信作者: 郭兆安
  • 基金资助:
    国家自然科学基金面上项目(81874440); 山东省中医药科技发展计划项目(2017-467)

Effect of endoplasmic reticulum stress and drug intervention on podocyte injury in diabetic nephropathy

Zhaoan Guo1,(), Lina Sun2   

  1. 1. Department of Nephrology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Provincial Hospital of Traditional Chinese Medicine, Ji′nan 250011
    2. Department of Nephrology, Linyi City People′s Hospital, Linyi 276000; Shandong Province, China
  • Received:2020-07-29 Published:2021-04-30
  • Corresponding author: Zhaoan Guo
引用本文:

郭兆安, 孙丽娜. 内质网应激及药物干预对糖尿病肾病足细胞损伤的作用[J]. 中华肾病研究电子杂志, 2021, 10(02): 96-99.

Zhaoan Guo, Lina Sun. Effect of endoplasmic reticulum stress and drug intervention on podocyte injury in diabetic nephropathy[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2021, 10(02): 96-99.

足细胞损伤或脱落会导致肾小球基底膜裸露且通透性增加,是糖尿病肾病(DN)持续进展的重要原因。内质网应激(ERS)是细胞的一种适应性反应。适度的ERS对细胞具有保护作用,而外界刺激强度超过内质网的自身保护平衡时,ERS会激活各种凋亡信号通路以清除受损细胞来保护内环境的稳定。糖尿病状态下,ERS信号通路会促进足细胞损伤和凋亡。因此,ERS信号通路及其关键因子,已成为防治DN的关键靶点。本文综述了ERS对糖尿病肾病足细胞损伤的影响及药物干预作用研究进展。

Podocyte injury or shedding will cause the glomerular basement membrane to be exposed and increase its permeability, which is an important reason for the continuous progression of diabetic nephropathy (DN). Endoplasmic reticulum stress (ERS) is an adaptive response of cells. Moderate ERS has a protective effect on cells, and when the intensity of external stimuli exceeds the self-protective balance of the endoplasmic reticulum, ERS will activate various apoptosis signaling pathways to remove damaged cells to protect the milieu interne stability. In the state of diabetes, the ERS signaling pathway can promote the injury and apoptosis of podocyte. Therefore, the ERS signaling pathway and its key factors have become the key targets for the prevention and treatment of DN. This article reviewed the progress of research on the effect of ERS in podocyte damage of diabetic nephropathy and on the drug intervention.

图1 ERS不同信号通路对糖尿病肾病足细胞的影响
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